摘要
目的研究奥氮平、利培酮以及阿立哌唑治疗慢性精神分裂症患者认知功能损害的疗效。方法选取2012年9月-2013年9月我院收治的慢性精神分裂症患者120例,按照随机数字表法将患者分为A组、B组和C组,每组40例。A组给予奥氮平,B组给予利培酮,C组给予阿立哌唑,治疗6个月,应用阳性和阴性症状量表（PANSS）评价患者治疗前后的精神状态,应用认知功能评定量表（LOTCA）评定患者治疗前后的认知功能,应用TESS量表评价药物的不良反应,比较三组治疗前后PANSS评分、LOTCA评分、TESS评分以及临床疗效。结果 A组总有效率为87.5%（35/40）,B组总有效率为85.0%（34/40）,C组总有效率为87.5%（35/40）,三组比较差异无统计学意义（χ^2=0.144,P=0.930〉0.05）;三组PANSS评分治疗后分别为（43.9±1.1）分、（44.1±0.9）分、（43.8±0.7）分,显著优于治疗前,与治疗前比较差异有统计学意义（t=135.820,192.078,166.590,P〈0.05）,三组比较无统计学意义[F0.05（2,117）=2.64,P〉0.05];三组LOTCA评分治疗后分别为（75.2±1.3）分、（74.9±1.5）分、（75.3±0.9）分,均显著优于治疗前,与治疗前比较差异有统计学意义（t=136.316,121.502,138.297,P〈0.05）,三组比较无统计学意义[F0.05（2,117）=2.79,P〉0.05];三组TESS评分治疗后分别为（13.2±0.7）分、（12.9±0.2）分、（13.3±0.7）分,三组比较差异无统计学意义[F0.05（2,117）=3.04,P〉0.05]。结论奥氮平、利培酮以及阿立哌唑均可以改善患者的认知功能,且三者之间疗效相当。
Objective To study the effect of olanzapine, risperidone and aripiprazole in treatment of cognitive impairment of chronic schizophrenia. Methods 120 cases with chronic schizophrenia were selected from our hospital during the period from September 2012 to September 2013, according to the random number table they were divided into A group, B group, C group. There were 40 cases in each group, the patients of the A group were given olanzapine, the patients of the B group were given risperidone, the patients of the C group were given aripiprazole. Three groups were treated 6 months, the positive and negative syndrome scale（PANSS） was used to evaluate the mental state before and after treatment, the assessment scale cognitive function（LOTCA） was used to evaluate cognitive function before and after treatment, the TESS scale was used to evaluate the adverse reactions, the PANSS score, LOTCA score and TESS score before and after treatment and clinical efficacy were compared. Results The total effective rate of group A was 87.5%（35/40）, the total effective rate of group B was 85.0%（34/40）, the total effective rate of group C was 87.5%（35/40）,there was no statistically significance in three groups（χ^2=0.144, P=0.9300.05）; After treatment the PANSS score of three groups were（43.9±1.1）,（44.1±0.9）,（43.8±0.7）, which were better than before, the differences were statistically significant（t =135.820, 192.078, 166.590, P 0.05）, there were no statistically significance differences in three groups[F0.05（2,117）=2.64, P〉0.05]; After treatment the LOTCA score of three groups were（75.2±1.3）,（74.9±1.5）,（75.3±0.9）, which were significantly better than before, the differences were statistically significant（t=136.316, 121.502, 138.297, P〉0.05）,there were no statistically significance in three groups [F0.05（2,117）=2.79, P〉0.05]; The TESS score of three groups were（13.2±0.7）,（12.9±0.2）,（13.3±0.7）, the differences were not statistically significant in three groups[F0.05（2,117）=3.04, P〉0.05].Conclusion Olanzapine, risperidone and aripiprazole can improve cognitive impairment of the patients, and they were quite efficacy in three groups.
出处
《中国现代医生》
2015年第1期34-36,共3页
China Modern Doctor
关键词
奥氮平
利培酮
阿立哌唑
慢性精神分裂症
认知功能
Olanzapine
Risperidone
Aripiprazole
Chronic schizophrenia
Cognitive impairment
