摘要
目的观察头颈部鳞状细胞癌组织中有丝分裂阻滞缺陷蛋白2(MAD2)的表达变化。方法头颈部鳞状细胞癌患者101例,分别取其肿瘤组织、肿瘤旁肌肉组织;以49例份正常头颈部肌肉组织作对照。采用免疫组化SP法检测上述组织标本中的MAD2。结果肿瘤组织、肿瘤旁肌肉组织、正常头颈部肌肉组织中MAD2的阳性表达率分别为90.1%、53.5%、46.9%;前者与后两者相比,P均<0.05。有、无淋巴结转移的头颈部鳞状细胞癌患者肿瘤组织中MAD2阳性表达率分别为96.6%、81.4%,两者相比,P<0.05。结论头颈部鳞状细胞癌组织中MAD2阳性表达率升高,其异常高表达可能参与了头颈部鳞状细胞癌的发生发展过程。
Objective To study the expression of mitotic arrest deficient-2 （ MAD2 ） in squamous cell carcinoma （ HNSCC） tissues from head and neck .Methods The MAD2 in 101 HNSCCs tissues and tumor adjacent tissues from 101 patients with HNSCC head and neck , neck muscles from 49 human normal were observed using immunohistochemistry .Re-sults The positive expression rates of MAD 2 in tumor tissues , para-carcinoma muscular tissues and normal head and neck-muscles were 90.1%, 53.5%and 46.9%respectively;there were significant differences between the former and the latter two（P〈0.05）.The positive rate of MAD2 in HNSCC tissues with/without local lymph node metastasis was 98.3% and 81.4%（P〈0.05）.Conclusion The positive expression rate of MAD2 has increased in HNSCC tissues.MAD2 may play an important role in the initiation and development of HNSCC .
出处
《山东医药》
CAS
2014年第43期80-81,共2页
Shandong Medical Journal
关键词
鳞状细胞癌
头颈部鳞状细胞癌
有丝分裂阻滞缺陷蛋白
染色体不稳定性
squamous cell carcinoma
head and neck squamous cell carcinoma
mitotic arrest deficient protein
chro-mosome instability
