摘要
目的分析超早期栓塞治疗对破裂颅内动脉瘤患者预后的影响。方法根据栓塞时间将270例患者分成2组:A组(动脉瘤破裂后24 h内行栓塞治疗)135例和B组(动脉瘤破裂24 h后行栓塞治疗)135例,对两组患者的临床特征进行单因素和多因素分析,观察超早期栓塞对临床治疗效果的影响。结果A、B两组患者入院时具有相似的临床及影像学特征。术后6个月临床结果显示,A组患者中预后良好(m RS 0~2分)122例(90.4%),而B组患者中预后良好110例(81.5%),两组比较,差异有统计学意义(P=0.036)。多因素Logistic回归分析显示,超早期栓塞治疗(P=0.021;OR,2.536;95%CI:1.637~5.116)为患者预后的一个独立影响因素。结论颅内动脉瘤破裂后24 h内进行栓塞治疗能够改善患者的预后。
Objective To discuss the impact of ultra-early embolization treatment on clinical outcome in patients with ruptured intracranial aneurysms.Methods A total of 270 patients with ruptured intracranial aneurysms were enrolled in this study.According the time to perform embolization with coils the patients were divided into group A(coiling being performed within 24 hours after the onset of rupture,n=135)and group B(coiling being performed 24 hours after the onset of rupture,n=135).The effect of ultra-early coiling embolization on clinical outcome was analyzed by using univariate analysis and multivariate logistic regression analysis.Results The patients of group A and group B had the similar clinical and imaging features at the time of admission.Six months after the treatment,good results(mRS 0-2)were obtained in 122 cases(90.4%)of group A and in 110 cases(81.5%)of group B.The difference in prognosis between the two groups was statistically significant(P=0.036).Multivariate logistic regression analysis showed that ultra-early embolization with coils(P=0.021;OR,2.536;95%CI,1.637-5.116)was an independent predictor indicating a better clinical outcome(mRS 0-2).Conclusion Ultra-early(within 24 hours after the onset of rupture)coiling can improve clinical outcome in patients with ruptured intracranial aneurysms.(J Intervent Radiol,2014,23:1029-1032)
作者
顾大群
张扬
晁迎九
魏建军
傅先明
牛朝诗
高歌
陈昱
余舰
GU Da-Qun;ZHANG Yang;CHAO Ying-jiu;WEI Jian-jun;FU Xian-ming;NIU Chao-shi;GAO Ge;CHEN Yu;YU Jian(Department of Neurosurgery,Affiliated Anhui Provincial Hospital,Anhui Medical University,Anhui Province 230001,China)
出处
《介入放射学杂志》
CSCD
北大核心
2014年第12期1029-1032,共4页
Journal of Interventional Radiology
关键词
动脉瘤
栓塞
时间
结果
aneurysm
embolization
time
outcome
作者简介
通信作者:顾大群,E-mail:gudaqun@126.com
