摘要
目的:研究玫瑰茄提取物对自发性高血压大鼠(SHR)的降压作用机制。方法:玫瑰茄提取物设置高、中、低3种剂量给SHR灌胃4周,测定SHR尾动脉血压和血液中NO、ET含量。结果:与对照组比较,玫瑰茄提取物2.0g/kg、1.0g/kg、0.5mg/kg剂量组SHR收缩压与舒张压均有不同程度降低,高剂量组较中、低剂量组降压效果更加显著。不同剂量的玫瑰茄提取物能显著降低SHR血液中ET含量和提高血清NO含量,随着剂量的增加影响的效果越明显。结论:玫瑰茄提取物具有一定的降血压作用,降压作用可能是通过降低血液中ET含量和提高NO含量实现的。
Objective ： To study the hypotensive effect of Hibiscus Sabdariffa extract on hypertension rats （ SHR ） . Methods： Compared with the control group, （ SHR ） rats were feed with high, medium, low dose of Hibiscus Sabdariffa extract for 4 weeks to investigate its effect on blood pressures and NO. ET content in blood.Results： Compared with the control group, Hibiscus Sabdariffa extract from 2.0g/kg, 1.0g/kg, 0.5mg/kg dose have respectively decreased the systolic and diastolic blood pressure, the effect of high dose hypotensive effect was better than the middle and low dose. Different doses of Hibiscus Sabdariffa extract could significantly reduce ET content and improve NO in blood of （ SHR ） rats, the effect of hypotensive is better with the increase of dose.Conclusions ： Hibiscus Sabdariffa extract has the function of reducing blood pressure, with （ SHR ） rats of antihypertensive effect may by lowering ET content and increase NO content.
出处
《实用中医药杂志》
2015年第1期2-4,共3页
Journal of Practical Traditional Chinese Medicine
