摘要
目的:评估奥卡西平单药治疗老年癫痫患者的认知功能的改变。方法:应用简易精神状态检查(MMSE)、日常生活能力量表(ADL)以及ACE-R量表对126例未经治疗的老年癫痫患者治疗前、治疗1个月后及治疗后6个月进行问卷调查。结果:奥卡西平对新诊断的老年癫痫患者在顺行性记忆、回忆与识别、语言的流畅性、命名、语言的理解和写作及空间知觉能力方面的评分都有显著改善(P<0.05;P<0.01)。结论:奥卡西平长期单药治疗对老年癫痫患者认知功能有保护作用。
Objective：To explore the effect of oxcarbazepine（OXC）on cognitive function and quality of life in elderly patients newly diagnosed with epilepsy,using Mini-Mental State Examination（MMSE）,ADL,and ACE-R.We report on 126 patients newly diagnosed with epilepsy in the elderly who were assigned to OXC.Methods：All 126 patients were examined with MMSE,ADL,and ACE-R before and 1month,6months after treatment with OXC.Results：Newly diagnosed epilepsy in the elderly patients,who had taken oxcarbazepine,exhibited a significantly better performance（P〈0.05,P〈0.01）in anterograde memory,recallment,verbal fluency,language comprehension and writing ability,identification,and spatial cognitive abilities.Conclusion：The results of this study suggest that OXC is effective to preserve cognitive functions and behavioral abilities as long-term monotherapy in epilepsy of the elderly.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2014年第6期910-913,共4页
Medical Journal of Wuhan University
关键词
癫痫
奥卡西平
认知功能障碍
Epilepsy
Oxcarbazepine
Cognitive Functions
作者简介
么冬爱，女，1965-，医学博士，副主任医师，副教授，主要从事癫痫、心脑血管病、头痛等神经系统疾病及临床心理疾病、身心障碍疾病的研究
通讯作者：章军建，男，1963-，医学博士，教授，博士生导师，主要从事脑血管病与神经心理学研究
