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雄激素受体与相关分子在雌激素受体阴性乳腺癌中相互作用的研究进展 被引量:2

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摘要 乳腺癌作为一组异质性很强的疾病日益成为严重危害女性健康的疾病之一,然而随着乳腺癌分子分型的日趋完善,人们逐渐对该疾病的本质有了更加清晰的认识.雌激素受体(ER)作为预测乳腺癌预后的独立因子,其作用已经有较为完善的解释.因此,在ER阴性的乳腺癌中,对不同分子表型的研究有着更为重要的意义.近年来,一些学者关注同样作为类固醇激素受体的雄激素受体(AR)与乳腺癌的关系[1-2].已有研究显示,AR在70%浸润性乳腺癌中表达,可将AR作为新的治疗靶点[3].同时学者们发现ER阴性乳腺癌中有一些常见的分子与AR相互作用.现对这些研究进展进行综述.
作者 赵霖 牛昀
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2014年第11期2639-2640,共2页 Chinese Journal of Experimental Surgery
基金 国家自然科学基金资助项目(81172532) 教育部长江学者和创新团队发展计划(TRT0743)
作者简介 通信作者:牛昀,Email:yunniu2000@126.com
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参考文献19

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