摘要
目的评价孕酮对脑损伤的神经保护作用。方法计算机检索2005~2014年关于孕酮治疗创伤性脑损伤（TBI）的随机对照临床试验,并用Revman 5.1软件对符合纳入标准的研究进行系统评价。结果本研究共纳入3个研究,Meta分析显示：孕酮和安慰剂对TBI患者的预后有差异性,且差异有统计学意义[病死率和格拉斯哥预后量表评分（4~5分）RR（95%CI）值分别为0.6（0.41~0.88）、1.61（1.18~2.27）,格拉斯哥昏迷量表评分均数差（MD）值为0.87（0.24~1.51）]。结论孕酮能降低TBI患者病死率,提高格拉斯哥预后量表和格拉斯哥昏迷量表评分,从而改善预后,促进患者神经功能恢复。
Objective To evaluate the neuroprotective effects of progesterone for brain injury. Methods Searching for the randomized controlled trials（RCTs） of the neuroprotective effects of progesterone for brain injury from 2005 to2014. Studies meeting the quality standard were analyzed by the software of Revman 5.1. Results Three trials were discovered in total. Meta analysis showed that the disparity between progesterone group and placebo group in prognosis were all significant. The value of relative risk（RR） and 95%CI of mortality and Glasgow outcome scale scores were 0.6（0.41-0.88） and 1.61（1.18-2.27） respectively. The value of mean difference of Glasgow coma scale scores was 0.87（0.24-1.51）. Conclusion The current evidence shows that progesterone can improve the prognosis and neurologic function of patients suffering traumatic brain injury by reducing the mortality and increasing the scores of Glasgow outcome scale and Glasgow coma scale.
出处
《中国医药导报》
CAS
2014年第30期50-53,共4页
China Medical Herald
关键词
孕酮
脑损伤
神经保护
META分析
Progesterone
Brain injury
Neuroprotection
Meta-analysis
作者简介
徐之良（1963-），男，博士，主任医师，硕士生导师．主要从事小儿血液免疫疾病研究。
[通讯作者]钟森（1963-），男，硕士，主任医师，硕士生导师，主要从事新生儿缺氧缺血性脑病研究。
