新生儿脐血糖化血红蛋白正常参考区间调查被引量：3

An investigation on the reference range of glycosylated hemoglobin A_(1c) in neonatal umbilical cord blood

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摘要目的：探讨正常新生儿糖化血红蛋白（HbA1 c ）的参考区间。方法使用亲和层析法检测1003例正常新生儿脐血标本 HbA1 c医学参考区间按 P2．5～P97．5计算。结果新生儿脐血 HbA1 c 呈正偏态分布，中位数为3．80％；95％医学参考值为3．46％～4．25％；新生儿性别、分娩方式对 HbA1 c结果无明显影响（P ＞0．05）；新生儿脐血 HbA1 c 与新生儿血糖水平呈正相关（r ＝0．118，P ＝0．028），与新生儿体重无明显相关性（r ＝0．064，P ＝0．168）。结论新生儿脐血 HbA1 c可用于监测新生儿血糖水平，确定其参考区间对临床有重要指导意义。 Objective To investigate the reference range of neonatal glycosylated hemoglobin A1 c （HbA1 c ）. Methods A total of 1 003 healthy infants were enrolled,and their blood samples from umbilical cord were collected. HbA1 c levels were determined by affinity chromatography,and were calculated according to P2.5 -P97.5 .Results The HbA1 c levels showed a positive skewness distribution.The median of HbA1 c levels was 3.80%.The 95% reference ranges for HbA1 c levels were 3.46%-4.25%.There was no significant influence of infants′sex and delivery ways on HbA1 c levels （P ＆gt;0.05）.There was a positive correlation between HbA1 c levels and the blood glucose of infants （r =0.1 1 8,P =0.028）and no correlation with the weight of infants （r =0.064,P =0.1 68）.Conclusions HbA1 c levels can help for monitoring the blood glucose of infants,and the reference range has an important significance in clinic.

作者章莉俞菁汪洁云顾琴李海川候雅萍龚波

机构地区上海市长宁区妇幼保健院检验科上海市长宁区妇幼保健院儿科

出处《检验医学》 CAS 2014年第11期1094-1096,共3页 Laboratory Medicine

关键词新生儿脐血糖化血红蛋白参考区间调查 Neonatal umbilical cord blood Glycosylated hemoglobin A1 c Reference range Investigation

分类号 R446.1 [医药卫生—诊断学]

作者简介章莉,女,1984年生,硕士,主要从事妇幼疾病诊断工作. 龚波,联系电话：021-62288686-3317.

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