摘要
用SOS反应原噬菌体诱导法筛检14种常用抗肿瘤药物的致突变性。经加入和不加入S9代谢活化系统试验,结果有9种药物呈阳性反应。筛选了阳性对照试剂及其适当浓度范围,为完善该检测方法、选配联合化疗方案、药品研究及控制有害的残留药物进入环境提供了依据。
The 14 kinds of common antineoplastic drugs were tested for their mutational by using the SOS induct test whether the S9 was added to or not. The results showed that 9 drugs were positive. The positive compare agents and proper concentrative range were also screened, The reference basis was provided for perfecting the test method, serecting combined chemotherapy, studies of drugs and control remains of harmful drugs from entering environment were carried out.
关键词
抗癌药
致突变
阳性对照剂
Antineoplastic drugs SOS react Mutagenesis Positive comparison agent
