摘要
目的 ：探讨巯基嘌呤甲基转移酶（thiopurine methyltransferase,TPMT）基因多态性与急性淋巴细胞白血病（acute lymphoblastic leukemia,ALL）6-巯基嘌呤（6-mercaptopurine,6-MP）化疗时不良反应的关系。方法：检索ALL不同TPMT基因多态性患者6-MP化疗不良反应的人数为效应指标的相关文献,选择符合入选标准的文献,应用Stata11.0软件对研究结果进行异质性检验和效应值合并,并进行敏感性分析和偏倚评估。结果：纳入TPMT基因多态性与ALL不良反应的文献共5篇,共计病例426例。白细胞减少与TPMT基因多态性关系固定效应模型OR=4.55,95%CI：1.92~10.80;肝脏损害与TPMT基因多态性关系固定效应模型OR=2.63,95%CI：1.40~4.93。结论：TPMT基因多态性与6-MP治疗所引起的白细胞减少、肝脏损害等不良反应显著相关,更可靠的结论尚需大样本进行进一步研究。
Objective：To investigate the relationship between thiopurine methyltransferase （TPMT） polymorphisms and thiopurine- induced adverse drug reactions（ADRs） in 6-macraptopurine（6-MP）of acute lymphoblastic leukemia （ALL）. Methods：Eligible articles that compared the frequency of TPMT polymorpbisms among thiopurine-tolerant and intolerant ALL patients were included. Statistical analysis was performed with STATA 11.0. Sub-analysis/sensitivity analysis and bias evaluation were also performed. Results： Five studies that investigated a total of 426 participants met our inclusion criteria. The incidence of TPMT gene mutation was increased 4.55-fold （95% CI：1.92-10.80,P = 0.001） and 2.63-fold （95% CI：1.40-4.93,P 〈 0.003）,respectively,in ALL patients with bone marrow toxicity （BMT） and thiopurine-induced hepatotoxicity,compared with controls. Conclusion：This meta-analysis suggests that the TPMT polymorphisms are associated with BMT and hepatotoxicity. We need father investigation based upen big sample to draw more realiable conclusions
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第9期1279-1283,共5页
Journal of Nanjing Medical University(Natural Sciences)
