摘要
目的探讨研究C-反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白细胞介素(IL-4)3种炎症细胞因子和血钾浓度以及血液中白细胞计数的改变,对急性ST段抬高性心肌梗死(STEMI)患者发生心血管事件的预测能力,为STEMI患者的早期诊断和治疗提供科学依据。方法选择2010年12月-2012年1月随机入选行冠脉造影患者120例,其中STEMI患者38例、稳定性心绞痛患者(SA)42例、正常冠脉对照组患者40例,分别采用Elisa方法检测CRF、TNF-α、IL-4以及常规检测血液血钾浓度及观察白细胞计数,对STEMI患者均于12h内行直接经皮冠状动脉介入手术,并观察治疗前后这些指标的变化。结果 STEMI患者血CRF、TNF-α、IL-4水平显著高于SA及正常对照组患者;且入院时STEMI患者白细胞显著升高、血钾浓度显著降低,与SA及正常对照组患者相比,差异有统计学意义(P<0.05)。结论冠心病患者入院时炎症因子和白细胞水平升高,血钾浓度降低可能表明STEMI的发生,对于早期STEMI的辅助诊断有极其重要的意义,值得临床进一步推广和研究。
OBJECTIVE To study the predictive ability of three kinds of inflammatory cytokines CRF,TNF-α,PIGF and serum potassium concentration and changes in blood leukocyte count for cardiovascular events in patients with acute ST-segment elevation myocardial infarction（STEMI）and provide a scientific basis for early diagnosis and treatment of STEMI.METHODS Totally 120 patients undergoing coronary angiography from Dec.2010 to Jan.2012 were enrolled randomly,including 38 patients with STEMI,42 patients with stable angina（SA）and 40 patients with normal coronary angiography as the control group.Elisa detection methods were used for three kinds of inflammatory cytokines（CRF,TNF-α,IL-4）and routine testing of blood potassium concentration was performed and changes in white blood cell count was observed.Patients with STEMI received percutaneous coronary interventional procedures within 12 hours,and the changes in these indicators before and after treatment were observed.RESULTS Blood CRF,TNF-α,PIGF levels in patients with STEMI were significantly higher than patients with SA and the normal control group.Moreover,WBC was significantly increased and potassium concentrations were significantly reduced in STEMI patients on admission,the difference was significant compared with SA and normal control groups（P〈0.05）.CONCLUSION Elevated inflammatory cytokine and WBC in patients with coronary heart disease on admission and decreased potassium concentration may indicate STEMI,which has an extremely important significance for early diagnosis of STEMI,worthy of further promotion and research.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第19期4810-4812,共3页
Chinese Journal of Nosocomiology
基金
沧州市科技局基金资助项目(131302018)
关键词
急性心肌梗死
炎症因子
血钾
白细胞计数
Acute myocardial infarction
Inflammatory cytokines
Serum potassium
Leukocyte count
