摘要
目的观察奥曲肽保守治疗直肠癌术后早期炎症性肠梗阻患者的临床疗效。方法选取2013年4月至2014年4月行保守治疗的直肠癌根治术后早期炎症性肠梗阻患者80例,随机分为治疗组和对照组,各40例。对照组进行禁食禁饮、持续胃肠减压、静脉营养支持、纠正酸碱平衡紊乱以及抗感染等常规治疗,治疗组在对照组治疗基础上加用奥曲肽,观察并记录两组患者的临床疗效、症状缓解状况、治疗前后胃肠减压引流量以及不良反应。结果治疗组总有效率为85.00%,明显高于对照组的55.00%(P<0.05)。治疗组患者腹痛腹胀缓解时间以及肛门排气排便时间均低于对照组,胃肠减压引流量明显比对照组少(P<0.05);两组患者不良反应主要是电解质紊乱以及白细胞异常,不良反应发生率组间比较无明显差异(P>0.05)。结论奥曲肽用于术后早期炎性肠梗阻的保守治疗临床疗效好,且不良反应并无增加,值得临床推广。
Objective To observe the clinical efficacy of octreotide in the conservative treatment of early inflammatory ileus after colorectal cancer operation. Methods 80 cases of early inflammatory ileus after the radical operation of colorectal cancer in our hospital from April 2013 to April 2014 were selected and randomly divided into the treatment group and the control group, 40 cases in each group. The control group was given the routine therapy of fasting and water- deprivation, continuous gastrointestinal decompression, intravenous nutritional support, correcting acid- base balance disorders and anti- infection, while on this basis the treatment group was added with octreotide. The clinical efficacy, symptomatic alleviation condition, drainage volume of gastrointestinal decompression before and after treatment, and adverse reactions were observed and recorded. Results The total effective rate was 85.00% in the treatment group and 55.00% in the control group, the difference was statistically significant（P〈0.05）,the relief time of abdominal pain and abdominal distension and the time of anal exhaust and defecation in the treatment group were shorter than those in the control group, the drainage volume of gastrointestinal decompression in the treatment group was significantly less than that in the control group, the difference was statistically significant（P〈0.05）; the adverse reactions in the two groups were mainly the electrolyte imbalance and abnormal WBC, comparing the two groups showed no statistical difference in the occurrence of adverse reactions（P 〉 0. 05）. Conclusion Octreotide has better clinical effect without increasing adverse reactions for the conservative treatment of early postoperative inflammatory ileus and is worthy of being promoted in clinic.
出处
《中国药业》
CAS
2014年第19期95-96,共2页
China Pharmaceuticals
关键词
奥曲肽
术后早期炎症性肠梗阻
临床疗效
octreotide
early postoperative inflammatory ileus
clinical efficacy
作者简介
金宗英（1969-），女，大学本科，主要从事临床肛肠科工作，（电子信箱）huangsihetuoren@163．com；
钟旗（1963-），女，主要从事临床肛肠科工作，本文通讯作者，（电子信箱）838414630@qq．com.
