摘要
Objective To study the relationship between resting heart rate and blood lipid level. Methods A total of 9 415 subjects aged≥40 years were included in the present study. Their resting heart rate was monitored and their serum levels of triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Results The subjects were divided into group A with their resting heart rate〈70 beats/min, group B with their resting heart rate=70-79 beats/min, group C with their resting heart rate=80-89 beats/min, and group D with their resting heart rate≥90 beats/min. High TG, TC, and LDL-C were presented across the resting heart rate （Ptrend〈0.01）. Multiple logistic regression analysis revealed that the risk of high TG and TC was higher in subjects with their resting heart rate≥90 beats/min than in those with their resting heart rate〈70 beats/min （OR=1.42;95%CI：1.16-1.74 and OR=1.33;95%CI：1.09-1.64, respectively）. Conclusion Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects.
Objective To study the relationship between resting heart rate and blood lipid level. Methods A total of 9 415 subjects aged≥40 years were included in the present study. Their resting heart rate was monitored and their serum levels of triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Results The subjects were divided into group A with their resting heart rate〈70 beats/min, group B with their resting heart rate=70-79 beats/min, group C with their resting heart rate=80-89 beats/min, and group D with their resting heart rate≥90 beats/min. High TG, TC, and LDL-C were presented across the resting heart rate （Ptrend〈0.01）. Multiple logistic regression analysis revealed that the risk of high TG and TC was higher in subjects with their resting heart rate≥90 beats/min than in those with their resting heart rate〈70 beats/min （OR=1.42;95%CI：1.16-1.74 and OR=1.33;95%CI：1.09-1.64, respectively）. Conclusion Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects.
基金
supported by grants from the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health(1994DP131044)
National Nature Science Foundation of China(81170739,81170719,81270877,81222008)
Shanghai New Excellent Youth Program(XYQ2011009)
the Shanghai Health Bureau Grant(2011293)
作者简介
Biographical note of first author： SUN Ji Chao, male, born in 2988, PhD candidate, majoring in Biochemistry and Molecular Biology of Type 2 Diabetes Mellitus.Correspondence should be addressed to XU Min, MD, PhD; Tel： 86-21-64370045, Ext： 663340; Fax： 86-21-64749885; E-mail： della.xumin@ 163.com
