摘要
Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time （〉6 months）. However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xeno- antigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.
猪胰岛细胞异种移植是一种极具潜力治疗糖尿病的方法。其临床应用主要面临两大挑战:高质量的活性胰岛短缺与异种免疫排斥反应。合适的猪供体筛选(年龄、性别、品系、基因表型)是获取充足的高性能胰岛移植物的重要前提,并可有效地减轻胰岛异种抗原性及体内异种排斥反应,进而延长移植物的功能存活时间。在文中,我们总结了异种移植中猪胰岛的相关研究进展,为供体猪的筛选提供了依据;同时表明了无特殊病原体的成年转基因猪可能是目前最佳的异种胰岛供体,有望在未来的临床研究中大规模应用。
基金
supported by the National Natural Science Foundation of China(No.30700772)
作者简介
Corresponding author E-mail： zht0915@ 163.com;Corresponding author bobwang75@yeah.net
