摘要
目的:制备并研究新型多孔聚甲基丙烯酸甲酯/磷酸钙骨水泥的聚合温度、材料成分、机械特性、孔隙率等临床应用相关特性,为进一步开发理想骨水泥修复材料提供理论依据。方法:在传统聚甲基丙烯酸甲酯骨水泥制备的基础上,以羧甲基纤维素钠和α-磷酸三钙作为成孔剂和骨引导剂,制备不同组分的多孔聚甲基烯酸甲酯/磷酸钙骨水泥,用热电偶、x射线衍射仪、体式显微镜、显微CT和MTS材料试验系统分别评价合成产物的最高聚合温度、材料成分、孔隙率、孔径大小、机械特性等特征。结果:具有骨引导性的α-磷酸三钙能成功载入多孔聚甲基烯酸甲酯支架中,生成的产物具有安全的聚合温度。不同含量的羧甲基纤维素钠会影响支架中孔径的大小,但不会影响孔隙率(P=0.102)。虽然α-磷酸三钙的载入会降低孔隙率(P<0.001),但所有产物之间的抗压强度和弹性模量无显著性差异(P=0.724,P=0.601)。结论:多孔聚甲基丙烯酸甲酯支架能与α-磷酸三钙成功复合成具有适宜机械性能的生物材料,这为开发理想骨水泥修复材料提供了新的思路。
Objective： To prepare novel porous polymethylmethacrylate （PMMA） / calcium phosphate bone cements and investigate their clinic--related properties, e.g. polymerization temperature, composition characterization, mechanical property and porosity. Methods： Sodium carboxymethylcellulose （Na-CMC） and α-tricalcium phosphate （α-TCP） were introduced into PMMA matrix to generate interconnected pores and improve the osteoconductivity, respectively. Four different porous PMMA based cements were prepared and then evaluated by thermal couple, X-ray diffraction, stereomicroscope, μ- CT and MTS testing machine. Results： The osteroconductive α-TCP powders were successfully loaded into the porous PMMA matrix and the polymerization temperature was close to the body temperature. The concentration of CMC had effects on the pore size but not the porosity of PMMA （P =0. 102）. On the other hand, the incorporation of α-TCP lowered the porosity （P〈0. 001） but did not affect the mechanical properties of the material （P=0. 724, P=0. 601）, Conci^i0n＇i Porous i^MMA scaffold arid α-TCP cah be combined to establish a promising biomaterial which shows adequate clinic-related property.
出处
《口腔医学研究》
CAS
CSCD
2014年第8期732-735,739,共5页
Journal of Oral Science Research
基金
教育部博士研究生学术新人奖(5052012304001)
中央高校基本业务费专项基金(2012304020201)
关键词
聚甲基丙烯酸甲酯
磷酸钙
骨水泥
Polymethylmethacrylate Calcium phosphate Bone cement
作者简介
作者简介撒悦（1985～），男，陕西汉中人，博士研究生，主要从事El腔颌面部硬组织的结构和再生的研究工作。
通讯作者王贻宁，电话：027—87686318
