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成纤维生长因子受体1在乳腺癌中的研究进展 被引量：3

Research progress on fibroblast growth factor receptor 1 in breast carcinoma
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摘要 成纤维生长因子受体(fibroblast growth factor receptors,FGFRs)是肿瘤形成中涉及的多个分子之一,并在细胞增殖、血管生成和迁移中发挥重要作用。文中回顾FGFR信号通路在乳腺癌中的作用、与发病风险和预后的相关性及FGFRs作为乳腺癌潜在治疗靶点的作用,讨论了靶向FGFR1在临床试验中的多种治疗策略。 Fibroblast growth factor receptor （FGFR） is one of the molecules involved in tumor formation, and plays an important role in cell proliferation, angiogenesis and migration. In this article, we review the role of FGFR signal pathway in breast cancer, the correlation with the risk and prognosis, the function of FGFRs as potential therapeutic targets for breast cancer and discuss various treatment strategies of targeted FGFR1 in clinical trials.
作者 张丽霞 李庆霞
机构地区 河北医科大学肿瘤学教研室 河北省人民医院肿瘤科
出处 《医学研究生学报》 CAS 北大核心 2014年第8期884-887,共4页 Journal of Medical Postgraduates
基金 河北省科学技术厅基金(11276103D-70)
关键词 碱性成纤维生长因子 成纤维生长因子受体1 信号通路 乳腺癌 Basic fibroblast growth factor Fibroblast growth factor receptor 1 Signaling pathway Breast cancer
分类号 R737.9 [医药卫生—肿瘤]
作者简介 医学硕士研究生 通讯作者：李庆霞，E—mail：lqx73@163．com.
  • 相关文献

参考文献29

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二级参考文献72

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共引文献18

同被引文献25

  • 1TURNER N, GROSE R. Fibroblast growth factor signalling: from development to cancer[J]. Nature reviews Cancer, 2010, 10(2): 116-129.
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引证文献3

二级引证文献9

医学研究生学报
2014年 第8期

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