摘要
目的探讨腺苷蛋氨酸与多烯磷脂酰胆碱治疗酒精性肝硬化的疗效。方法选取酒精性肝硬化患者92例,随机分为腺苷蛋氨酸组30例,多烯磷脂酰胆碱组30例,联合组32例,分别采用腺苷蛋氨酸、多烯磷脂酰胆碱和二者联合进行治疗,对三组患者疗效进行比较。结果与治疗前比较,治疗后三组患者各项指标均有显著变化(P<0.05);且联合组各项指标变化幅度显著优于腺苷蛋氨酸组和多烯磷脂酰胆碱组,两两相比,差异有统计学意义(P<0.05);联合组总有效率(96.88%)明显优于腺苷蛋氨酸组(83.33%)和多烯磷脂酰胆碱组(73.33%);三组比较,差异有统计学意义(P<0.05)。结论采用多烯磷脂酰胆碱与S-腺苷蛋氨酸治疗酒精性肝硬化,两药均能显著改善肝功能,但二者联合应用后,改善程度及治疗效果均明显提高,值得临床借鉴和应用。
Objective To investigate the effect of S-adenosylmethionine and Polyene phosphatidyl choline in the treatment of alcoholic cirrhosis. Methods Ninety-two cases of patients with alcoholic cirrhosis were selected and ran- domly divided into three groups. Thirty cases of S-adenosylmethionine group were treated with S-adenosylmethionine while 30 cases of polyene phosphatidyl choline group were treated with Polyene phosphatidyl choline. And 32 cases of combination group were treated with Polyene phosphatidyl choline combined with S-adenosylmethionine. The efficacy of three groups was compared. Results After treatment, all the indicators among three groups were significantly changed （P 〈 0.05） ; and the changes in the combination group was significantly better than those in the Adenosylmethionine group and Polyene phosphatidyl choline group （P 〈 0. 05 ）. The total effective rate of the combination group was 96.88% and it was significantly better than that of the Adenosylmethionine group （83.33%） and Polyene phosphatidyl choline group （73.33%） （P 〈 0.05）. Conclusion The treatment of Polyene phosphatidyl choline and S-adenosylme- thionine for alcoholic cirrhosis can significantly improve liver function, but the effect is significantly improved when they were combined, which is worthy to clinical application.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第8期927-929,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
腺苷蛋氨酸
多烯磷脂酰胆碱
肝硬化
Adenosylmethionine
Polyene phosphatidyl choline
Cirrhosis
作者简介
陈予，硕士，E-mail：chenyutg@126．com
