摘要
目的观察托拉塞米及呋塞米对糖尿病肾病(diabetic nephropathy,DN)水肿的临床疗效。方法将60例DNⅣ期水肿患者随机分为呋塞米静脉注射组(对照组)、托拉塞米静脉注射组(托拉塞米A组)、托拉塞米持续泵入组(托拉塞米B组)。监测患者治疗前、治疗后第1天、第4天及第7天24小时尿量、血肌酐、血钾及血钠;治疗前及治疗后第7天脑钠肽(BNP)指标变化。结果治疗前,3组患者24小时尿量、血肌酐、血钾及血钠比较差异无统计学意义;治疗后,托拉塞米A组及B组24小时尿量均高于对照组,而托拉塞米B组较托拉塞米A组尿量增加(P<0.01);3组患者血肌酐水平、血钾比较差异无统计学意义(P>0.05);与治疗前比较,3组患者血钠均较前下降,但托拉塞米B组降钠作用强于其他两组;3组患者治疗后第7天BNP均明显下降(P<0.01)。结论托拉塞米利尿作用强于呋塞米,托拉塞米采用持续静脉泵入具有更强的利尿作用。
Objective To observe the clinical curative effect of torasemide and furosemide on diabetic nephrotic edema.Methods Sixty cases of diabetic nephropathy（stageⅣ）with edema were randomly divided into three groups：furosemide intravenous injection group（control group）,torasemide intravenous injection group（torasemide group A）,torasemide continuous intravenous pumping group（torasemide group B）.24 hour urine volume,serum creatinine,serum potassium and serum sodium of the patients were detected before treatment,1day,4days and 7days after treatment.Brain natriuretic peptide（BNP）was detected before and seven days after treatment.Results Before treatment,the patients of the three groups had no significant difference in 24 hurine volume,serum creatinine,serum potassium and serum sodium.After treatment,24 hour urine volume in torasemide group A and B were higher than that in control group,while that in torasemide group B was higher than in torasemide group A（P〈0.01）.There were no statistically significant difference in serum creatinine,serum potassium level among three groups（P〉 0.05）.After treatment,serum sodium of three groups was decreased,and the effect of torasemide group B was stronger than that of the other two groups.Seven days after treatment,BNP in three groups was all significantly decreased（P 〈0.01）.ConclusionDiuretic effect of torasemide is stronger than furosemide,and continous intravenous pumping of torasemide has stronger diuretic effects.
出处
《临床荟萃》
CAS
2014年第9期1002-1004,共3页
Clinical Focus
关键词
糖尿病肾病
水肿
利尿
托拉塞米
呋塞米
diabetic nephropathy
edema
diuresis
torasemide
furosemide
作者简介
通信作者：罗洋，Email：luoyang96@163．com
