摘要
目的:比较参芪十一味颗粒联合EOX方案与单纯EOX方案治疗晚期胃癌的疗效及毒副反应。方法:将经病理学或细胞学和影像学确诊为晚期胃癌患者作为研究对象,均有可客观测量的病灶,分为参芪十一味颗粒联合EOX方案组(参芪组)33例及单纯EOX方案组(对照组)27例。每例患者至少接受治疗2周期以上。结果:参芪组27例部分缓解(PR)12例,稳定(SD)9例,总有效率为44.4%;对照组27例获PR 11例,SD 8例,总有效率为40.7%;两组疗效比较无显著性差异(P>0.05)。参芪组白细胞减少的发生率、III-IV度胃肠道反应和肝肾毒性显著少于对照组(P<0.05)。参芪组生活质量Karnofsky评分提高率58%,对照组提高率30%,两组差异有显著性(P<0.05)。结论:参芪十一味颗粒能够减少EOX方案化疗毒副作用,增加患者化疗耐受性,提高生活质量。
Objective： To observe and compare the efficacies and toxicities of compound shenqishiyiweikeli combined with EOX regimen （ Epirubicin ＋ Oxaliplatin ＋ Capecitabine） and EOX regimen alone in the treatment of patients with advanced gastric carcinoma. Methods：Patients with advanced gastric carcinoma, diagnosed by histopathology, cytology and imaging, were divided into 2 groups. They were treated with EOX regimen alone （control group, n = 25 ） or combination with compound shenqishiyiweikeli （ shenqishiyiwei group, n = 25 ）. Each pationts received at least 2 cycles of the treatments. Results ： In shenqishiyiwei group, the overall response rate was 44.4% （ PR in 12 patients, SD in 9 patients, and PD in 6 patients）. In control group, the overall response rates was 40.7% （PR in 11 patients, SD in 8 patients, and PD in 8 patients）. The difference in the overall response rates between the two groups was insignificant （ P 〉 0.05 ）. The increase rate of Karnofsky score for the quality of life （58.0%） in shenqishiyiwei group was significantly higher than that （30%） in control group （P 〈 0.05 ）. The incidence rates of leucopenia, grade Ⅲ - Ⅳ gastrointestinal reations, hepatotoxicity reactions, hepatotoxicity and renal toxicity in shenqishiyiwei group were significantly lower than those in control group（ P 〈 0. 05 ）. Conclusion：Compound shenqishiyiweikeli can attenuate toxic effects of EOX chemotherapy,enhance patients＂ tolerance to chemotherapy and improve patients＇ quality of life.
出处
《辽宁中医杂志》
CAS
2014年第8期1693-1695,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
参芪十一味颗粒
胃癌
化疗
compound shenqishiyiweikeli
gastric carcinoma
chemotherapy
作者简介
诸亮（1981-），女，陕西延安人，主治医师，硕士，研究方向肿瘤的内科治疗。
