摘要
目的探讨血尿酸(SUA)、β2微球蛋白(β2-MG)、脂蛋白(a)[Lp(a)]和C反应蛋白(CRP)在老年高血压患者引起早期肾损伤中的临床应用价值。方法根据临床诊断将210例原发性老年高血压患者作为研究对象和50例健康老年人作为健康对照,分别测定其SUA、β2-MG、Lp(a)和CRP水平并进行统计分析;根据内生肌酐清除率(Cr)将这210例高血压患者又分单纯高血压组和高血压肾病组,观察这4项指标的变化情况。结果高血压组SUA、β2-MG、Lp(a)和CRP水平明显升高且高于对照组,差异有统计学意义(P<0.05)。根据血压升高程度分组研究:高血压1级,高血压2级,高血压3级组的SUA、β2-MG、Lp(a)和CRP水平呈趋势性升高,差异有统计学意义(P<0.05);高血压肾病组与单纯高血压组比较:SUA、β2-MG、LP(a)和CRP水平显著升高,差异有统计学意义(P<0.05)。结论监测老年高血压患者SUA、β2-MG、LP(a)和CRP水平,可有效监测老年高血压患者肾功能的早期受损,可更快地、更有效发现其患者的肾脏病变,有利于临床医生早期对其进行诊治。
Objective To explore the clinical application value of blood uric acid（SUA）,beta 2 microglobulin（β2-MG）,lipopro-tein（a）[LP（a）]and C-reactive protein（CRP）in the early renal damage caused by elderly hypertension.Methods According to the clinical diagnosis,210 elderly patients with primary hypertension were selected as the research subjects and 50 healthy elderly per-sons as the healthy control.The SUA,β2-MG,LP（a）and CRP levels were detected.The differences were compared between the groups with the different severity degrees of hypertension and the healthy control group;Furthermore,these 210 cases of hyperten-sion were divided into the simple hypertension group and the hypertensive renal group according to the creatinine clearance rate （Ccr）for observing the changes of the four indicators.Results The blood SUA,β2-MG,LP（a）and CRP levels in the hypertension group were significantly increased,which were higher than those in the normal control group,the differences had statistical signifi-cance（P〈0.01）;In the study by grouping according to the increase degree of blood pressure：the blood SUA,β2-MG,LP（a）and CRP levels in the three groups of the grade 1,2,3 hypertension were significantly increased,the statistical analysis showed the sig-nificant difference between groups（P〈0.05）;Compared with the simple hypertension group,the SUA,β2-MG,LP（a）and CRP lev-els were significantly increased compared with the hypertensive renal group,the difference showed the statistical significance（P 〈0.05）.Conclusion Monitoring blood SUA,beta 2-MG,LP（a）and CRP levels in elderly patients with hypertension can effectively monitor the early renal function damage in the patients with senile hypertension,can find the renal lesions more rapidly and effec-tively and is conducive to early diagnosis and treatment in clinic.
出处
《国际检验医学杂志》
CAS
2014年第16期2166-2167,2170,共3页
International Journal of Laboratory Medicine
作者简介
王修石，男，主管技师，主要从事临床检验研究。
