摘要
端粒酶和端粒长短的变化与人类肿瘤的发生发展息息相关。其中,发生在端粒酶逆转录酶(telomerase reverse transcriptase,TERT)启动子区域的体细胞突变对泌尿生殖系统肿瘤的发生具有重大影响。此外,TERT的表达已被证明与肿瘤患者预后不佳相关。旨在总结TERT在泌尿生殖系肿瘤发生发展中可能的作用以及揭示TERT作为判断疾病预后的生物标志物和肿瘤靶向治疗新靶点的巨大潜能。
Telomerase and the control of telomere length are closely related to the development of human cancer. Mutations in the promoter region of telomerase reverse transcriptase （TERT） will have an enormous impact on the tumourigenesis process of urogenital tumour. In addition, the expression of TERT has also been proved to have correlations with poor prognosis. This article summarizes the current potential roles of TERT in the tumorigenesis and development of urogenital carcinoma, suggests that TERT holds promise as a biomarker for the evaluation of prognosis, and has great potential as the basis for targeted therapies.
出处
《生命科学》
CSCD
2014年第8期804-808,共5页
Chinese Bulletin of Life Sciences
基金
国家重点基础研究发展计划("973"项目)(2014CB745200)
国家自然科学基金项目(81301740)
深圳市基础研究项目(JCYJ20130401114928183
JCYJ20130401114715714)
关键词
端粒酶逆转录酶
泌尿生殖肿瘤
靶向治疗
telomerase reverse transcriptase
urogenital carcinomas
targeted therapy
作者简介
通信作者：E-mail：547349961@qq．com
通信作者：E—mail：doctor_wusong@126．com
