摘要
目的研究壮肾灵方外敷联合西药治疗对心肾阳虚、水瘀内阻型慢性心力衰竭患者的心功能影响。方法 140例心肾阳虚、水瘀内阻型慢性心力衰竭患者随机分为2组,治疗组70例采用西药联合壮肾灵外敷心俞、肾俞;对照组70例西药联合安慰剂外敷。两组连续治疗12周,观察治疗前后中医证候积分、心功能分级、血浆脑钠肽(brain natriuretic peptide,BNP)、6min步行距离。结果治疗组治疗12周后,心功能分级改善有效率、中医证候积分疗效总有效率、BNP水平改善明显优于对照组(P<0.05)。两组6min步行距离治疗前后比较,差异无统计学意义(P>0.05)。结论壮肾灵外敷联合西药口服能够改善心肾阳虚、水瘀内阻型慢性心力衰竭患者的心功能。
Objective To observe the effect of external application of Zhuangshenling Recipe （ZR） combined with Western medicine （WM） on the heart function of chronic heart failure （CHF） patients of Xin-Shen yang deficiency, interior retention of water-fluid syndrome （XSYDIRWFS）. Methods Totally 140 CHF patients of XSYDIRWFS were randomly assigned to two groups, the treatment group and the control group, 70 in each group. All patients received WM therapy. Those in the treatment group were applied with ZR at Xinshu （BL15） and Shenshu （BL23）, while those in the control group were applied with placebos at Xinshu （BL15） and Shenshu （BL23）. The therapeutic course for all was 12 weeks. The integrals of TCM syndrome, grading of cardiac function, brain natriuretic polypeptide （BNP）, and 6 rain walking distance were observed before and after treatment. Results After twelve weeks of treatment, the effective rate of improved grading of cardiac function, the total effective rate of TCM syndrome efficacy, and the BNP level were obviously better in the treatment group （P 〈0.05）. There was no statistical difference in 6 rain walking distance between the two groups （P 〉0.05）. Conclusion External application of ZR combined with WM could improve the heart function of CHF patients of XSYDIRWFS.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2014年第7期808-811,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
2011年广东省建设中医药强省立项资助课题(No.20111092)
关键词
壮肾灵方
心肾阳虚
水瘀内阻证
慢性心力衰竭
外治法
Zhuangshenling Recipe
Xin-Shen yang deficiency syndrome
chronic heart failure
external application
作者简介
通讯作者：傅晓霞，Tel：0759—3279985，E-mail：Fu_tiger@Sina．com
