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EML4-ALK融合基因在肿瘤中的研究进展 被引量：2

EML4-ALK fusion gene in tumor
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摘要 棘皮动物微管结合蛋白4（EML4）-间变淋巴瘤激酶（ALK）融合基因作为近几年新发现的肿瘤相关基因，在多种肿瘤组织中表达。目前针对EML4-ALK融合基因的研究仍以非小细胞肺癌为主，以该融合基因为治疗靶点的ALK抑制剂已经逐渐推向临床。EML4-ALK融合基因与表皮生长因子受体（EGFR）-Kras突变相关性的研究亦为肿瘤的靶向治疗提供了新思路。 EML4-ALKfusiongeneisoneofthenoveltargetsinthetherapyoflungcancer,whichcan be detected in several kinds of tumors.A specific ALK inhibitor has been shown to exert anti-tumor effects in non-small cell lung cancer with the EML4-ALK fusion gene.Correlative study between EML4-ALK gene fusion and EGFR-Kras mutations might cast new insight on the tumor target therapy.
作者 郭易楠 岳文涛
机构地区 首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所细胞生物学实验室
出处 《国际肿瘤学杂志》 CAS 2014年第7期484-487,共4页 Journal of International Oncology
关键词 肿瘤 EML4-ALK融合基因 Neoplasms EML4-ALKfusiongene
分类号 R730.5 [医药卫生—肿瘤]
作者简介 通信作者：岳文涛，E-mail：yuewt2000@yahoo．com
  • 相关文献

参考文献25

  • 1Soda M, Choi YL, Enomoto M, et al. Identification of the transfor- ming EML4-ALK fusion gene in non-small-cell lung cancer [ J ]. Nature, 2007, 448 (7153 ) :561-566.
  • 2Soda M, Takada S, Takeuchi K, et al. A mouse model for EMIA- ALK-positive lung cancer[ J]. Proc Natl Acad Sci USA, 2008, 105 (50) : 19893-19897.
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  • 4Zhang X, Zhang S, Yang X, et al. ciated with development of lung ad KRAS mutations and is correlated Cancer, 2010, 9:188.
  • 5Fusion of EMIA and ALK is asso- lacking EGFR and with ALK expression [ J ]. Mol Perner S, Wagner PL, Demichelis F, et al. EML4-ALK fusion lung cancer: a rare acquired event [ J ]. Neoplasia, 2008, 10 (3) : 298- 302.
  • 6Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EMIA- ALKIJ]. J Clin Oncol, 2009, 27(26):4247-4253.
  • 7Takeuehi K, Choi YL, Togashi Y, et al. KIFSB-ALK, a novel fusion oneokinase identified by an immunohistoehemistry-based diagnostic system for ALK-positive lung cancer[ J]. Clin Cancer Res, 2009, 15 (9) :3143-3149.
  • 8Lin E, Li L, Guan Y, et al. Exon array profiling detects EMIA-ALK fusion in breast, colorectal, and non-small cell lung cancers[ J]. Mol Cancer Res, 2009, 7(9) :1466-1476.
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二级参考文献36

  • 1Soda M,Choi YL,Enomoto M,et al.Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.Nature,2007,448(7153):561-566.
  • 2Wong DW,Leung EL,So KK,et al.The EML4 ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS.Cancer,2009,115(8):1723-1733.
  • 3Shaw AT,Yeap BY,Mino-Kenudson M,et al.Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.J Clin Oncol,2009,27(26):4247-4253.
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  • 5全国肿瘤防治研究办公室/全国肿瘤登记中心/卫生部疾病预防控制局.2009全国肿瘤登记年报.北京:军事医学科学出版社.2010.
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  • 8Zhang X,Zhang S,Yang X,et al.Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.Mol Cancer,2010,9:188.
  • 9Wu SG,Kuo YW,Chang YL,et al.EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wildtype EGFR.J Thorac Oucol,2012,7(1):98-104.
  • 10Rodig SJ,Mino-Kenudson M,Dacic S,et al.Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population.Clin Cancer Res,2009,15(16):5216-5223.

共引文献95

同被引文献11

  • 1Li W,Qu J,Xu Z.Clinical features and mutation status of EGFR,KRAS,BRAF,EML4-ALK and ROS1between surgical resection samples and non surgical resection samples in lung cancer[J].J Thorac Dis,2015,7(5):875-880.
  • 2Zhao N,Zheng SY,Yang JJ,et al.Lung adenocarcinoma harboring concomitant EGFR mutation and EML4-ALK fusion that benefits from three kinds of tyrosine kinase inhibitors:a case report and literature review[J].Clin Lung Cancer,2015,16(2):e5-9.
  • 3Li T,Maus MK,Desai SJ,et al.Large-scale screening and molecular characterization of EML4-ALK fusion variants in archival non-small-cell lung cancer tumor specimens using quantitative reverse transcription polymerase chain reaction assays[J].J Thorac Oncol,2014,9(1):18-25.
  • 4Borrelli N,Giannini R,Proietti A,et al.KIF5B/RET fusion gene analysis in a selected series of cytological specimens of EGFR,KRAS and EML4-ALK wild-type adenocarcinomas of the lung[J].Lung Cancer,2013,81(3):377-381.
  • 5Toyokawa G,Taguchi K,Ohba T,et al.First case of combined small-cell lung cancer with adenocarcinoma harboring EML4-ALK fusion and an exon 19EGFR mutation in each histological component[J].J Thorac Oncol,2012,7(12):e39-41.
  • 6Xiao Z,Sperl B,Ullrich A,et al.Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres(cancer stem cells)irrespective of EGFR,KRAS,EML4/ALK and LKB1status[J].Oncotarget,2014,5(24):12877-12890.
  • 7林小梅,莫娟梅,邹敏,曾爱屏,于起涛,周韶璋,宋向群.EGFR突变的非小细胞肺癌患者EML4-ALK融合基因的检测及其临床特征分析[J].中国病理生理杂志,2012,28(6):1135-1139. 被引量：20
  • 8方平,封国红,林林,胡斌,吴昊,糜叶俊.EML4-ALK融合基因与EGFR基因突变在肺腺癌中的表达[J].医学研究杂志,2013,42(7):109-112. 被引量：3
  • 9王梦,杨继元,李军川,陈延煊.EML4-ALK在非小细胞肺癌中的表达及临床意义[J].临床肿瘤学杂志,2013,18(8):688-690. 被引量：8
  • 10张邢松,魏万里.肺癌组织中EML4-ALK基因表达的研究进展[J].现代肿瘤医学,2014,22(5):1226-1230. 被引量：4

引证文献2

二级引证文献4

国际肿瘤学杂志
2014年 第7期

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