摘要
目的探讨中药复方治疗非酒精性脂肪肝的用药规律。方法检索中国期刊全文数据库(1979年1月-2014年1月)、中文科技期刊数据库(1989年1月-2014年1月)和中国生物医学文献数据库(1979年1月-2014年1月)公开发表文献中治疗非酒精性脂肪肝的中药复方,建立相应数据库,采用频次分析、聚类分析和关联规则分析方法对中药复方进行数据挖掘。结果共获得治疗非酒精性脂肪肝的中药复方107个,涉及药物179种、频次1499次;以使用频次≥10次的37种作为主要药物进行聚类分析,归为活血药、清热药、利湿药、补气药、消积药、化痰药、补阴药、行气药和泻下9大类;经关联规则分析,共得有趣关联规则33条,药对30对。结论数据挖掘有助于解读中药复方治疗非酒精性脂肪肝的用药规律。
Objective To explore the regularities and rules of compound herbal formulae for nonalcoholic fatty liver disease （NAFLD）.Methods Compound herbal formulae on NAFLD published in journals of CNKI （1979.1-2014.1）, VIP （1989.1-2014.1） and CBMdisc （1979.1-2014.1） were analyzed with association rule, frequency analysis and cluster analysis.Results In 107 prescriptions, 179 herbs were involved, and frequency of usage of those herbs was 1499. A cluster analysis was used to analyze 37 herbs with high frequency （≥10） of usage, which were classified into 9 clusters including promoting circulation, clearing heat herb, diuretic herb, food stagnation herb, regulating qi herb, phlegm-resolving herb, qi tonics herb, yin-nourishing herb, qi-activating herb and purgating herb. 30 pairs of herbs and 33 rules for NAFLD were obtained by association rule analysis.Conclusion It was a point of view to understand the regularities and rules of Chinese herb prescription on NAFLD by data mining.
出处
《中国中医药信息杂志》
CAS
CSCD
2014年第8期38-41,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
上海市中医药学会资助课题(2013年)
上海市静安区卫生系统学科建设项目(JWXK201206)
关键词
非酒精性脂肪肝
数据挖掘
中药复方
用药规律
nonalcoholic fatty liver disease
data mining
compound herbal formulae
regularities and rules of prescription
作者简介
通讯作者：张天嵩，E-mail：ztsdoctor@126．com
