摘要
目的 探讨2型糖尿病患者冠状动脉病变程度与血清胱抑素C（Cys C）的关系.方法 选取2011年10月至2013年10月2型糖尿病患者180例,经冠状动脉造影分为冠心病组与非冠心病组,比较两组血清Cys C的差异;同时按冠心病严重程度分为单支病变组、双支病变组及多支病变组,比较三组间血清Cys C水平的差异.应用多因素非条件Logstic逐步回归分析法分析2型糖尿病合并冠心病的危险因素.结果 血清Cys C水平糖尿病非冠心病组[（0.83±0.16）mg/L]低于糖尿病冠心病组[（1.06±0.14）mg/L].随着冠心病严重程度的加重,血清Cys C水平不断升高,甘油三酯、糖化血红蛋白、血清Cys C与冠心病存在相关性,血清Cys C为糖尿病合并冠心病的独立危险因素（OR=1.230）.结论 血清Cys C水平与2型糖尿病患者冠心病的发生、发展及预后密切相关,可能成为冠心病的一项重要预测指标.
Objective To investigate the relationship between extent of coronary artery disease and serum cystatin C （Cys C） in patients with type 2 diabetic.Methods From 2011 October to 2013 October 180 cases of patients with type 2 diabetes mellitus were enrolled,and were divided into CHD group and non CHD group according the results of coronary angiography.The difference of serum cystatin C was compared between the two groups;according to the severity of coronary lesions,the patients were divided into single,double branch lesions and multi vessel disease group,the difference of serum cystatin C level was compared among three groups.The risk factors of type 2 diabetes with coronary heart disease were analyzed by non condtional Logistic regression analysis of multifactor.Results The serum Cys C level in diabetic non CHD group [（0.83±0.16）mg/L was lower than that of diabetic coronary heart disease group （1.06±0.14）mg/L].With the aggravation of the severity of coronary artery disease,serum cystatin C levd increased.The glycosylated hemoglobin,triglyceride,serum cystatin C were correlated with coronary heart disease,and serum cystatin C was independent risk factors of diabetes mellitus complicated with coronary heart disease（OR=l.230）.Conclusion The serum Cys C level may relate with the occurrence,development and prognosis of type 2 diabetic with coronary heart disease,may be an important predictor of coronary heart disease.
出处
《中国心血管病研究》
CAS
2014年第7期595-597,共3页
Chinese Journal of Cardiovascular Research
作者简介
通讯作者：赖杰，E—mail：laijie19790811@163．com
