摘要
目的 探讨胆总管结石患者血清CA19 9变化的临床意义。方法 采用放射免疫法检测血清CA19 9水平。胆、胰的良、恶性疾病患者 117例 ,分成 3组 :急、慢性胆囊炎组 31例 ,胆总管结石组 46例 ,胰腺癌组 40例。结果 39.13%的胆总管结石患者CA19 9有不同程度的提高 (正常值为 <37U/ml) ,最高值 >10 0 0U/ml,平均为 (10 3.2± 2 43.5 )U/ml,高于胆囊炎组 ,显著低于胰腺癌组。胆总管结石组CA19 9的升高率同其余两组相比 ,差异有显著性 (P <0 .0 1) ,且血清总胆红素水平与CA19 9呈正相关 (r =0 .32 1,P <0 .0 5 )。结论 胆总管结石可导致血清CA19 9水平升高 ,与黄疸程度存在一定的相关性 ,但CA19 9不能作为判别良。
Objective To appraise the clinical significance of serum CA19-9 changes in choledocholithiasis patients. Methods One hundred and seventeen patients suffering from benign or malignant disease of biliary tract and pancreas were detected the serum CA19-9 level by using radioimmunity assay. These patients were divided into three groups: 31 cases of acute or chronic cholecystitis group, 46 cases of choledocholithiasis group and 40 cases of pancreatic cancer group. Serum total bilirubin level in choledocholithiasis patients was also measured. Results Increase of CA19-9 was observed in 39.13% of choledocholithiasis group, with a mean valve (103.2± 243.5) U/ml and the highest> 1 000 U/ml. There was a significant difference between the mean value of CA19-9 of choledocholithiasis and cholecystitis groups ( P < 0.05), but lower than that of pancreatic cancer group( 421.7± 401.2) U/ml( P < 0.001). The increase of CA19-9 was positively correlated with increase of serum total bilirubin. Conclusions Calculus of common bile duct may lead to rise of serum CA19-9, and such change parallel with level of jaundice. So confident discrimination of benign and malignant disease can not be relied solely on an elevated CA19-9 measurement.
出处
《上海医学》
CAS
CSCD
北大核心
2002年第7期411-413,共3页
Shanghai Medical Journal
