摘要
目的评价降钙素原(PCT)联合白介素-6(IL-6)在重症肺炎中的诊断价值。方法收集89例社区获得性肺炎患者,分为重症肺炎组25例、普通肺炎组64例以及18例健康者为对照组。入院后24小时内采集PCT、IL-6标本并用免疫荧光法进行检测,同时记录各组患者的外周血血常规、红细胞沉降率、C反应蛋白(CRP)、细菌培养结果。结果重症肺炎组中PCT及IL-6值分别为(14.77±6.14)ng/mL、(271.8±57.95)mg/L,明显高于其他两组,差异有统计学意义(P<0.05),普通肺炎组中两者均高于对照组,但差异无统计学意义。根据ROC曲线图,以PCT>0.08 ng/mL为截断值,诊断细菌感染的敏感性为85.9%,特异性为67.6%;以IL-6>14 mg/L为截断值,诊断细菌感染的敏感性为57%,特异性为83.8%。结论 PCT与IL-6在重症肺炎诊断中具有重要价值,同时检测二者有利于重症肺炎的诊治。
Objective To evaluate the diagnosis of serum procalcitonin (PCT)and inter-leukin-6 (IL-6 )in severe pneumonia. Methods 89 patients who underwent community acquired pneumonia in our hospital from Jan.2012 to Sep.2013 were divided into severe pneumonia group with 25 patients and mild pneumonia group with 64 patients,and compared with the 18 healthy people.during the first 24 hours who were hospitalized,the specimens were collected,PCT and IL-6 levels were determined using Fluorescence immunoassay regularly,at the same time,the following parameters were assessed,such as white blood cell count,erythrocyte sedimentation rate(ESR),C-reactive protein (CRP)and bacterial culture of both sputum and blood.Results The Mean ±SD of PCT and IL-6,respectively were(14.77 ±6.14)mg/L and(271.8 ±57.95)mg/L in severe pneumonia group,which was significantly higher than that in mild pneumonia group and control group (P<0.05),the Mean ±SD of PCT and IL-6 in mild pneumonia group were also higher than that in control group,but the P-value >0.05. Depending on Receiver operator characteristic(ROC)curves,at a cut-off value,0.08 ng/mL PCT,the sensitivity was 85.9%,the specificity was 67.6%,at a cut-off value,14 mg/L IL-6,the sensitivity was 57%,the specificity was 83.8%.Conclusion Serum PCT and IL-6 play an important diagnosis value in severe pneumonia,at the same time detection,which is helpful for the diagnosis and treatment of severe pneumonia.
出处
《安徽医学》
2014年第7期881-883,共3页
Anhui Medical Journal
基金
安徽医科大学2012年校科学研究基金项目(2012xkj080)
关键词
降钙素原
白介素-6
重症肺炎
Procalcitonin
Inter-leukin-6
Severe pneumonia
