摘要
晚期糖基化终产物 (AGEs)是体内蛋白质与糖在无酶条件下发生反应后的产物。大量实验表明 :AGEs与糖尿病、血管性疾病、衰老以及肾脏疾病等多种疾病密切相关。在这些疾病的发展过程中 ,AGEs发挥了重要作用。一方面 ,AGEs直接参与疾病的发生 ,影响细胞和组织功能 ,另外 ,它还通过与特异受体结合 ,来介导一系列病理反应。该文从AGEs的产生过程。
Advanced Glycation End products (AGEs) are the products of non enzymatic glycationprotein. It has been demonstrated that AGEs are closely correlated to a variety of diseases such as diabetes,vascular complications,aging and renal diseases. AGEs play important roles in the development of these diseases. They can effect the function of cells and tissues directly, and also mediate pathological reactions through binding with special receptors. The present paper reviews the procedures of AGEs production,action mechanism and pathology of AGEs.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2002年第3期246-249,共4页
Chinese Pharmacological Bulletin
基金
教育部"高等学校骨干教师资助计划"资助课题
No 2 0 0 10 0 2 3 0 0 4
