摘要
以纯品灰树花多糖PGF - 1为原料 ,研究了其对S180 肉瘤生长的抑制作用及对荷瘤小鼠免疫功能的影响。结果表明 ,在口服给药 5 0～ 15 0mg/kg·d的剂量下 ,PGF - 1对小鼠S180 肉瘤的抑制率为 2 0 .5 7%～ 34.75 %。经免疫试验发现PGF能明显增加荷瘤小鼠的胸腺指数、淋巴细胞转化能力。
The inhibitory ability to S 180 and effect on immunological function in tumor bearing mice of polysaccharide of Grifola frondosa (PGF-1) were studied. Results showed that when the polysaccharide of Grifola frondosa (PGF-1) was taken orally by S 180 bearing mice at the dosage of 50～150 mg/kg·d , the inhibitory rate of tumor S 180 was 20.57%～34.75%. PGF-1 can also enhance thymus index,delayed type hypersensitivity,the ability of splenic lymphocyte proliferation and formation of antibody in splenic cells, and promote the production of IgM hemolysin significantly in S 180 bearing mice.
出处
《华中农业大学学报》
CAS
CSCD
北大核心
2002年第3期261-263,共3页
Journal of Huazhong Agricultural University
基金
湖北省"十五"重点科技攻关计划资助项目 (2 0 0 1AA2 0 4B0 3 )
关键词
灰树花
多糖
PGF-1
荷瘤小鼠
免疫功能
Grifola frondosa , polysaccharide, anti tumor effect, immunological function
