摘要
目的探讨临床常用的口服降糖药物格列吡嗪及二甲双胍和对Ⅱ型糖尿病人血清胰岛素样生长因子_1,2(IGF_1 ,2)的影响。方法采用治疗前后自身对照研究 ,分别给予格列吡嗪或二甲双胍治疗2wk ,比较两种药物对Ⅱ型糖尿病患者空腹IGF_1,IGF_2血清水平的影响。结果二甲双胍治疗组(25例)空腹血清IGF_1 ,IGF_2治疗后无明显变化 ;格列吡嗪(40例)治疗后空腹血清IGF_1升高[(181.8±104.5)vs(209.0±88.2)ng·ml-1 ,(P<0.05)],IGF_2治疗后无明显变化 ;治疗后2组血糖均明显下降(P均<0.01) ,格列吡嗪组治疗后C肽水平明显升高(P<0.05),二甲双胍组治疗后C肽水平无明显变化。结论格列吡嗪和二甲双胍对Ⅱ型糖尿病患者血清IGF_1水平有不同的影响。
Aim To study the effects of glipizide and metformin on the serum IGF_1,IGF_2 in patients with type Ⅱ diabetes mellitus;Methods The effect of glipizide(n=40) and metformin(n=25) on serum IGF_1,IGF_2 in patients with type Ⅱ diabetes mellitus were compared with self_ controlled study.Results In metformin_treated patients ,there were not significantly changes in fasting IGF_1 and IGF_2 concentrations,In glipizide_treated patients,there were markedly increased IGF_1 concentrations (181.8±104.5) vs (209.0±88.2) ng·ml-1(P<0.05) while serum IGF_2 was not change.There was a significant reduction of blood glucose in two groups at the end of treatment(both P<0.01),but C_peptide level was markedly increased(P<0.05) only in glipizide_treated patients. Conclusion The changes of IGF_1 is markedly different between metformin_treated and glipizide_treated patients with type Ⅱ diabetes mellitus.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2001年第1期38-40,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
