摘要
目的揭示CO2 超临界萃取的中国林蛙卵油 (eggoilofRanatemporariachensinensisDavid ,EORTCD)的镇静和抗惊厥作用。方法通过自主活动监测、协同巴比妥催眠和士的宁诱发惊厥等实验 ,探索中国林蛙卵油的药效和最大效能 ,并与安定、佳静安定进行比较。结果EORTCD对小鼠自主活动有明显的抑制作用 ,对戊巴比妥钠诱导的睡眠有协同效果 ,显著对抗士的宁引起的小鼠惊厥反应 ,通过最大效能比较EORTCD的抗惊厥潜伏期长于安定和佳静安定 ,最大效能三者在同一水平。结论EORTCD具有显著的中枢抑制作用 ,对惊厥动物产生保护作用。
Objective To search the central inhibition effect of the egg oil of Rana temporaria chensinensis David egg oil (EORTCD). Methods The spontaneous activity of mice was monitored, the cooperation of EORTCD with pentobarbital sodium was observed and the convulsant model was induced by strychnine. The pharmacodynamics and efficacy of EORTCD were tested by comparing with Diazepam and Alprazolam. Results EORTCD reduced the locomotor activity of mice, prolonged the sleep duration induced by pentobarbital and exerted an anti convulsion action in strychnine mice. EORTCD showed more effective than Diazepam.and Alprazolam in the prolongation of latency in convulsing mice, and it got the same with Diazepam and Alprazolam in the comparation in efficacy, Conclusions EORTCD indicated a potent anti convulsant effect and protected convulsing animals strongly.
出处
《沈阳药科大学学报》
CAS
CSCD
2002年第3期204-207,共4页
Journal of Shenyang Pharmaceutical University
基金
辽宁省抚顺市科委资助项目
关键词
中国林蛙卵油
中枢抑制
镇静
抗惊厥
中枢抑制作用
动物实验
egg oil of Rana temporaria chensinensis David
central inhibition
sedation
anti convulsant
efficacy curve
