摘要
夜间哮喘发作是临床上经常遇到的情况。本文通过5例对照组,6例慢支单纯组为对照,对9例哮喘组病人血浆24小时皮质醇水平变化,24小时尿皮质醇含量分别测定,部分患者检测了最大呼气流量。发现血中皮质醇正常昼夜变化节律的改变,哮喘组明显高于对照组及慢支单纯组(P<0.05);并且发现了夜间血中皮质醇水平降低先于最高呼气流量降低约4小时的规律,依据哮喘的发病机理为炎性改变的学说及皮质醇延时的作用认识认为夜间血中皮质醇的降低是产生夜间哮喘发作可能的主要原因;并提出血中皮质醇水平正常节律的紊乱也是引发夜间哮喘的另一个可能的重要原因。
Nocturnal attacks often happen in patients with asthma.Five patients in controlgroup and 6 patients with chronic bronchitis were reported,we measured changesof plasma corticosteroids in 24 hours to 9 patients with asthma.The peak expiratoryflow rate(PEFR)were measured in some of them.Observing the changes ofcircadian for plasma corticosteroids,it was found that it was significantly higherin the asthma group than in the control group and bronchitis group(P<0.05).Gene-rally,a decrease in level of plasma corticosteroids at night about 4 hours earlierthan PEFR.Basing on the mechanism that asthma was suggested inflammation andplasma corticosteroids action was delayed,it was believed that a decrease in plasmacorticosteroids at night was one of the important reasons to nocturnal asthmaattack,and circadian disorder in plasma corticosteroid's level was also anotherimportant factor.
出处
《天津医药》
CAS
1991年第1期36-39,共4页
Tianjin Medical Journal
关键词
哮喘
血浆
皮质醇
生理节律
nocturnal asthma
plasma corticosteroid
circadiant
