摘要
目的 :探讨非霍奇金淋巴瘤 (NHL)免疫球蛋白重链 (IgH)和T细胞受体δ链 (TCRδ)基因重排情况。 方法 :用半重叠式聚合酶链反应 (PCR)方法检测IgH及TCRδ基因重排。 结果 :5 7例NHL中 4 1例 (72 % )发生IgH基因重排 ,30例 (5 3% )出现TCRδ基因重排。结论 :检测克隆性基因重排可以作为诊断NHL有效基因标志 。
Purpose To explore the clonal rearrangements of immunoglobulin heavy chain (IgH) and T cell receptor gene δ chain (TCR δ) in non Hodgkin's lymphoma (NHL). Methods Semi nested polymerase chain reaction (PCR) was used to study IgH and TCR δ genes rearrangements in 57 cases of NHL. Results IgH gene rearrangements were found in 41 patients,and TCR δ gene rearrangements in 30 cases. Conclusion To detect the clonality can be served as a genetic marker in the diagnosis of NHL. The lineage infidelity does occur in NHL.
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第1期21-23,共3页
Chinese Journal of Clinical and Experimental Pathology
