摘要
烟雾病是以双侧颈内动脉末端慢性进行性狭窄或闭塞为特征,并继发颅底异常血管网形成的一种脑血管疾病,目前病因未明。研究结果显示近10%的亚洲患者中存在家族史,在不同族裔和性别群体发病率不同,并证实了烟雾病存在遗传易感性。本文对近年来烟雾病相关基因研究进行综述,为烟雾病的早期诊断及治疗提供理论基础。
Objective Moyamoya disease (MMD), a progressive cerebrovascular disorder that is characterized as bilateral stenosis/occlusion of the distal infernal carotid arteries and formation of collateral vessel networks. At present, its etiology have not been fully elucidated. Nearly up to 10 percent of MMD population in Asia were endowed with family histories. Previous studies had revealed that MMD have genetic susceptibility and different incidence rates across ethnic and gender groups. In the present study, domestic and foreign studies on genetics of MMD were summarized, and theoretical guidances for early diagnosis and treatment were provided.
作者
张泼
何跃
王宝峰
王和平
郭东生
Zhang Po;He Yue;Wang Baofeng;Wang Heping;Guo Dongsheng(Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2019年第2期384-388,共5页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金 (81472364、81671154、81702480、81874086).
关键词
烟雾病
遗传学
易感基因
Moyamoya disease
Genetics
Susceptibility gene
作者简介
通信作者:郭东生,Email:guodongsheng@163.com.
