摘要
目的研究磁共振全身扩散加权成像(WBDWI)在肺癌化疗疗效评估中的价值,为优化临床影像学检查提供循证依据。方法选取临汾市中心医院2017年10月至2018年5月经病理检查证实的肺癌患者60例,分别于化疗前、化疗2个周期后行WBDWI检查,对比化疗前后肿瘤大小、远处转移及表观扩散系数(ADC)值变化,对有效组ADC值变化率与肿瘤缩小率进行相关性分析。结果化疗后60例患者中有1例发现新发脑转移灶。治疗有效组化疗前后ADC值及肿瘤大小[ADC值:(1.12±0.33)×10^-3mm^2/s比(1.56±0.40)×10^-3mm^2/s;肿瘤大小:(4.63±2.75)cm比(2.28±1.45)cm]差异均有统计学意义(t=-3.954、4.711,均P<0.01)。治疗有效组ADC值变化和肿瘤长径变化有相关性(r=0.34,P<0.05)。结论WBDWI不仅可以快速有效地判断肿瘤体积的变化、有无远处转移,并通过ADC值的测定,能在肿瘤体积未发生变化之前观察肿瘤细胞的微观变化,预测肿瘤早期的治疗反应,对肺癌的分期及化疗疗效作出有效评价。
Objective To study the clinical value of whole-body magnetic resonance diffusion weighted imaging(WB-DWI) in evaluating the chemotherapy response for lung cancer, thus to provide evidence for optimizing clinical imaging examination. Methods From October 2017 to May 2018, 60 patients with lung cancer confirmed by histopathology in Linfen Central Hospital were selected.The patients underwent DWI examinations before chemotherapy and after two cycles of chemotherapy.The change of tumor size, distant metastasis and apparent diffusion coefficient(ADC) value were compared before and after chemotherapy.The correlation between the change rate of ADC value and the shrinkage rate of tumor size in the effective group was analyzed. Results Of 60 cases, 1 case had new cerebral metastases after chemotherapy.There were statistically significant differences in ADC value[(1.12±0.33)×10-3mm2/s vs.(1.56±0.40)×10-3mm2/s]and tumor size[(4.63±2.75)cm vs.(2.28±1.45)cm]between before and after chemotherapy in the effective group(t=-3.954, 4.711, all P<0.01). There was correlation between the change of ADC value and tumor size(r=0.34, P<0.05). Conclusion WB-DWI can not only detect the change of tumor size and distant metastasis quickly and effectively, but also can observe the microscopic changes of tumor cells by measuring ADC value.So it can predict the early therapeutic response of the tumor and make effective evaluation for the staging and chemotherapy response of lung cancer.
作者
张艳明
吕晓波
赵学红
张东峰
张信
柯娟
王玮
黄敏
李晓飞
贺红杰
张晓晶
翟玉峰
Zhang Yanming;Lyu Xiaobo;Zhao Xuehong;Zhang Dongfeng;Zhang Xin;Ke Juan;Wang Wei;Huang Min;Li Xiaofei;He Hongjie;Zhang Xiaojing;Zhai Yufeng(Department of Oncology ,Linfen Central Hospital ,Linfen ,Shanxi 041000,China)
出处
《中国基层医药》
CAS
2019年第1期6-9,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
山西省临汾市软科学研究项目(1716).
关键词
磁共振成像
磁共振成像
弥散
肺肿瘤
药物疗法
联合
肿瘤转移
肿瘤分期
技术评估
生物医学
预测
Magnetic resonance imaging
Diffusion magnetic resonance imaging
Lung neoplasms
Drug therapy, Combination
Neoplasm metastasis
Neoplasm staging
Technology assessment, Biomedical
Forecasting
作者简介
通信作者:张信,Email:zx271396191@sina.com,电话:0357-2399628.
