摘要
目的探究不同剂量利妥昔单抗注射液治疗难治性免疫性血小板减少症的疗效及对凝血指标的影响评价。方法选择我院2013年4月～2018年4月我院收治的难治性免疫性血小板患者110例,将其分为对照组和实验组,每组55例。两组同时采用利妥昔单抗注射液治疗,对照组的用药量为375mg/m^2,实验组的用药量100mg/m^2。对比两组患者的治疗效果和治疗总费用。结果实验组治疗总有效率78. 18%高于对照组61. 82%(P <0. 05);实验组的用药费用显著低于对照组(P <0. 05);实验组的不良反应少于对照组(P <0. 05)。结论小剂量应用利妥昔单抗注射液或标准剂量应用利妥昔单抗注射液对治疗难治性免疫性血小板减少症的疗效均显著,但小剂量用药安全性较高,不良反应少,费用低,值得临床应用。
Objective To investigate the effect of Rituximab injection in the treatment of refractory immune thrombocytopenia. Methods From April 2013 to April 2018,110 patients with refractory immune platelets were selected and divided into control group and experimental group with 55 cases in each group. Both groups were treated with Rituximab injection,the control group was 375 mg/m^2,and the experimental group was 100 mg/m^2. The effect and total cost of treatment were compared between the two groups. Results The total effective rate( 78. 18%) of the experimental group was significantly higher than that of the control group( 61. 82%,P < 0. 05),the cost of medication in the experimental group was significantly lower than that of the control group( P < 0. 05),and the adverse reaction of the experimental group was less than that of the control group( P < 0. 05). Conclusion The efficacy of low dose Rituximab injection or standard dose Rituximab injection in the treatment of refractory immune thrombocytopenia was significant. It is worthy of clinical application.
作者
赵秀娟
展新荣
Zhao Xiujuan;Zhan Xinrong(Department of Hematology,Second People's Hospital,Xinxiang City,Henan Province, Xinxiang 453000,China;Department of Hematology,Xinxiang Central Hospital,Henan Province,Xinxiang ,Henan 453000,China)
出处
《辽宁医学杂志》
2018年第6期32-33,43,共3页
Medical Journal of Liaoning
