摘要
目的探讨间苯三酚联合催产素对促进孕产妇产程的安全性,为孕妇生产提供临床参考。方法选择2016年9月-2017年8月来广州市荔湾区妇幼保健院分娩的孕产妇共85例,随机分为观察组和对照组,根据产前检查、胎儿的发育情况以及胎位胎盘附着情况选择合适的分娩方式。分娩初期,当其子宫颈口扩张至2～3 cm时,对照组给予生理盐水(500 ml)+催产素(2. 5 U)静脉滴注;观察组给予生理盐水(500 ml)+催产素(2. 5 U)+间苯三酚(80 mg)静脉滴注,记录孕产妇产程、产后2 h出血量以及住院时间等分娩情况,并对用药后孕妇及胎儿发生的不良反应,做统计学分析。结果相比对照组,观察组孕产妇的第一、二、三产程有明显缩短,差异有统计学意义(均P<0. 05),其中第一产程缩短最为显著;观察组孕产妇产后出血量明显减少,差异有统计学意义(t=2. 035,P<0. 05);观察组孕产妇的住院时间也明显缩短,差异有统计学意义(t=4. 332,P<0. 000)。结论间苯三酚联合催产素可加速子宫颈口扩张、减少产后出血量,缩短产程及孕妇住院时间,有助于孕产妇的顺利分娩,进而减少孕产妇在分娩过程中危险因素,对于孕产妇以及新生儿的健康有重要的意义。
Objective To explore the safety of phloroglucinol combined with oxytocin in promoting labor of pregnant women,provide a clinical reference for delivery. Methods Eighty-five pregnant women giving birth to their babies in Maternal and Child Health Care Hospital of Liwan District from September 2016 to August 2017 were selected and randomly divided into control group and observation group,according to prenatal examination,fetal development,and attachment of placenta,the optimal delivery mode was selected. When expansion of cervix was 2-3 cm,the pregnant women in control group were given intravenous drip of normal saline (500 ml) and oxytocin (2. 5 U),the patients in observation group were given intravenous drip of normal saline (500 ml),oxytocin (2. 5 U),and phloroglucin (80 mg). Labor stage,the amount of postpartum hemorrhage within two hours after delivery,and hospitalization time were recorded,the adverse reactions of pregnant women and fetuses after medication were analyzed statistically. Results Compared with control group,the time of the first,the second,and the third stages of labor in observation group shortened significantly (P<0. 05),especially the time of the first stage of labor.The amount of postpartum hemorrhage in observation group decreased significantly (t = 2. 035,P<0. 05). The hospitalization time in observation group shortened significantly (t = 4. 332,P<0. 000). Conclusion Phloroglucin combined with oxytocin can accelerate cervical expansion,reduce the amount of postpartum hemorrhage,shorten labor stage and hospitalization time,help smooth childbirth,and further reduce risk factors in the course of labor,which is important for maternal and newborn health.
作者
蔡朝霞
CAI Zhao-Xia(Department of Gynecology and Obstetrics,Maternal and Child Health Care Hospital of Liwan District,Guangzhou, Guangdong 510000,China)
出处
《中国妇幼保健》
CAS
2019年第2期267-269,共3页
Maternal and Child Health Care of China
基金
广州市荔湾区科技局项目(201704054)
关键词
间苯三酚
催产素
孕产妇
产程
安全性
Phloroglucin
Oxytocin
Pregnant woman
Labor stage
Safety
