摘要
目的探讨大鼠颈总动脉(CCA)端端吻合在初学者显微技术训练中的价值。方法随机选取来自全国不同地区神经外科医生,且未进行过专门显微技术训练的初学者53名作为研究对象,同时随机选取健康雄性SD大鼠116只,分别行颈总动脉端端吻合术,并在吻合完成后检查即时血管通畅情况、吻合时间(自放置阻断夹至松开阻断夹)、吻合针数,并在24小时后检查次日血管通畅情况及存活率。结果 116只SD大鼠中,麻醉致死率约为6. 0%(7/116),大出血致死率约为4. 3%(5/116),最终有效研究对象104例,平均缝合6. 32针,平均用时64. 82 min,即时血管通畅率85. 6%(89/104),次日血管通畅率50. 0%(52/104),术后次日大鼠存活率100%(104/104)。结论大鼠颈总动脉端端吻合术后的即时、次日血管通畅率均较高,术后存活率高,可以作为未进行过专门显微技术训练的神经外科显微技术初学者训练的一种较好的动物模型。
Objective To investigate the value of end-to-end anastomosis of the common carotid artery( CCA) in microtechnique training for beginners. Methods A total of 53 neurosurgeons who came from different regions of China and did not receive professional microtechnique training were selected. A total of 116 male Sprague-Dawley rats were randomly selected. End-to-end anastomosis of the CCA was performed;the patency of the blood vessels,time for anastomosis( from the placement of the clamp to the release of the clamp),and number of stitches for anastomosis were observed immediately after anastomosis,and the patency of the blood vessels and survival rate were observed at 24 hours after anastomosis. Results Of all 116 rats,7(6. 0%) died of anesthesia and 5(4. 3%) died of hemorrhage,resulting in a total of 104 valid cases. The mean number of stitches was 6. 32 and the mean time for anastomosis was64. 82 minutes. The patency rate of blood vessels was 85. 6%(89/104) immediately after anastomosis and 50. 0%(52/104) on the next day,and the survival rate was 100%(104/104) on the next day. Conclusions There is a high patency rate of blood vessels immediately and the next day after the end-to-end anastomosis of the CCA,as well as a high survival rate after anastomosis. Therefore,it can be used as an appropriate animal model for microtechnique training for beginners in the department of neurosurgery.
作者
胡业帅
钱海
刘方军
石祥恩
HU Ye-shuai;QIAN Hai;LIU Fang-jun;SHI Xiang-en(Department of Neurosurgery,Sanbo Brain Hospital Capital Medical University,100093;Department of Neurosurgery ,Fuxing Hospital affiliatied to Capital Medical University,100038)
出处
《国际神经病学神经外科学杂志》
2018年第6期606-608,共3页
Journal of International Neurology and Neurosurgery
关键词
颈总动脉
端端吻合
显微技术训练
SD大鼠
初学者
Common carotid artery
End-to-end anastomosis
Microtechnique training
Sprague-Dawley rat
Beginner
作者简介
胡业帅(1985-),男,博士,主治医师,主要从事缺血性脑血管病及脑肿瘤的研究;通信作者:石祥恩,男,博导,教授,主任医师,主要从事颅外内血管搭桥的基础与临床研究、颅咽管瘤的手术治疗及下丘脑保护,E-mail:shixen@sina.com。
