摘要
婴儿血管瘤是婴幼儿时期最常见的良性肿瘤,源于血管内皮细胞的异常增生。婴儿血管瘤分为增殖期、退化期、退化完成期3个阶段。尽管婴儿血管瘤具有自限性,但因其生长迅速且易发生溃疡,可影响重要器官功能及美观,甚至危及生命。普萘洛尔目前已经成为高风险血管瘤的一线用药,多项研究证实其具有安全性及有效性。本文主要对普萘洛尔治疗婴儿血管瘤的适应征及禁忌症、剂量及疗程、有效性及安全性及复发等方面进行阐述。
Infantile hemangioma(IH)is a common benign tumor in infancy caused by abnormal proliferation of endothelial cell.IH usually undergoes three stages:proliferation,involution,the completion of involution.Although most IH is self-limiting,the rapid growth and risk of ulceration can affect the function of vital organs and even be life-threatening.Propranolol has been accepted as one of the first options in the treatment of high risk of IH,as a number of studies have confirmed its safety and effectiveness.Here we review Propranolol in the treatment of IH,including indications and contraindications,dosage and course of treatment,effectiveness and safety and recurrence.
作者
冯晴
李丽
尉莉
徐子刚
马琳
FENG Qing;LI li;WEI Li;XU Zigang;MA lin(Beijing Children's Hospital,Beijing 10032,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2019年第2期226-230,共5页
The Chinese Journal of Dermatovenereology
基金
首都卫生发展科研专项项目(2016-2-2093)
北京市属医院科研培育计划项目(PX2016014)
关键词
普萘洛尔
婴儿血管瘤
剂量
疗程
安全性
复发
Propranolol
Infantile hemangiomas
Dosage
Course
Safety
Recurrence
作者简介
通讯作者:马琳,E-mail:bch_maleen@aliyun.com.
