摘要
目的探讨血必净对胰十二指肠切除术后炎症反应的影响及其临床应用价值。方法采用回顾性病例对照研究方法,回顾性分析2016年1月至2017年9月南方医院收治的120例因恶性肿瘤行胰十二指肠切除术患者的临床资料,按术后是否使用血必净注射液分为血必净组和对照组,其中对照组60例,术后给予基础药物治疗;血必净组60例,在基础药物治疗的基础上给予血必净注射液治疗。比较两组患者术前及术后1、3、5 d发热情况及炎症指标(C反应蛋白、血白细胞计数、血中性粒细胞百分比)水平,同时比较两组患者围手术期死亡率、术后住院时间、住院费用情况。结果两组患者均治愈出院,无围手术期死亡。血必净组患者术后1、3 d的C反应蛋白水平、血白细胞计数、血中性粒细胞百分比显著低于对照组(P <0. 05,P <0. 01)。对照组术后发热发生率为73. 3%(44/60),高于血必净组的53. 3%(32/60)(χ2=5. 217,P=0. 022)。在术后住院时间及住院费用方面,两组对比差异无统计学意义(P均> 0. 05)。结论血必净应用于胰十二指肠切除术安全有效,具有良好的抗炎作用,有一定的临床应用价值。
Objective To explore the effects of Xuebijing injection on inflammatory response after pancreaticoduodenectomy and its clinical value. Methods A retrospective case-control study was conducted to analyze the clinical data of 120 patients who underwent pancreaticoduodenectomy for malignant tumors in Nanfang Hospital from January 2016 to September 2017. All patients were divided into Xuebijing group in which Xuebijing injection was given on the basis of conventional treatment and control group in which basic drug therapy was performed( n = 60,each). The body temperature and the inflammation indexes of C-reactive protein( CRP),leukocytes,neutrophil percentage were observed before operation and on 1-,3-and 5-day after operation and compared between two groups. The perioperative mortality rate,hospital stay and hospitalization expenses were also compared between two groups. Results All patients were cured and discharged without perioperative death. The levels of CRP,leukocytes and neutrophil percentage on postoperative 1-,3-day in Xuebijing group were significantly lower than those in control group( P < 0. 05,P < 0. 01). The incidence of postoperative fever in control group was significantly higher than that in Xuebijing group( 73. 3% vs 53. 3%,χ^2= 5. 217,P= 0. 022). There were no statistical differences in postoperative hospital stay and hospitalization expenses between two groups( all P > 0. 05). Conclusion Xuebijing injection has anti-inflammatory effect after pancreaticoduodenectomy with safety and has a certain clinical application value in clinic.
作者
梁晓路
王恺
周杰
LIANG Xiao-lu;WANG Kai;ZHOU Jie(Department of Hepatobiliary Surgery,Nanfang Hospital of Southern Medical University,Guangzhou,Guangdong 510515,China)
出处
《中国临床研究》
CAS
2019年第1期50-52,56,共4页
Chinese Journal of Clinical Research
基金
2016年国家自然科学基金青年项目(81600462)
广州市科技计划项目(201400000001-3)
2016年度南方医院杰青培育计划(2016006)~~
关键词
胰十二指肠切除术
炎症反应
围手术期
血必净
Pancreaticoduodenectomy
Inflammatory response
Perioperative period
Xuebijing injection
作者简介
通讯作者:周杰,E-mail:jacky@smu.edu.cn.
