摘要
目的观察鳖甲煎丸联合恩替卡韦(ETV)胶囊治疗乙肝肝硬化肝功能代偿期患者的效果。方法选取我院2016年1月至2018年1月收治的78乙肝肝硬化肝功能代偿期的患者,随机分为研究组和对照组各39例。对照组采用ETV胶囊治疗,研究组在对照组基础上采用鳖甲煎丸治疗。观察治疗前后两组患者的TBIL、 ALT、 ALB、 HBV-DNA、 FibroScan值以及不良反应情况。结果治疗后,两组患者的HBV-DNA转阴率比较差异无统计学意义(P>0.05)。治疗后,两组患者的FibroScan值和TBIL水平下降, ALB水平上升,且研究组的FibroScan值和TBIL、 ALB水平均明显优于对照组(P均<0.05)。研究组的不良反应发生率低于对照组(P <0.05)。结论采用鳖甲煎丸联合ETV治疗乙肝肝硬化肝功能代偿期患者,能够改善其FibroScan值,提高ALB水平,降低TBIL水平和不良反应发生率。
Objective To observe the effect of Biejiajian pills combined with entecavir(ETV)capsules on patients during hepatic functional compensatory period of hepatitis B liver cirrhosis.Methods 78 cases of patients during hepatic functional compensatory period of hepatitis B liver cirrhosis admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into study group and control group,with 39 cases in each group.The control group was treated with ETV capsules,while the study group was treated with Biejiajian pills on the basis of the control group.The TBIL,ALT,ALB,HBV-DNA and FibroScan value before and after treatment,and adverse reactions of the two groups were observed.Results After treatment,no statistical difference was found in the HBV-DNA negative conversion rate between the two groups(P>0.05).After treatment,the FibroScan values and TBIL levels of the two groups decreased,and the ALB levels increased(all P<0.05);The FibroScan value,TBIL and ALB levels of the study group were significantly better than those of the control group(all P<0.05).The incidence of adverse reactions of the study group were lower than that of the control group(P<0.05).Conclusions Biejiajian pills combined with ETV in the treatment of patients during hepatic functional compensatory period of hepatitis B liver cirrhosis can improve the FibroScan value and ALB level,and reduce the TBIL level and incidence of adverse reactions.
作者
许世申
XU Shishen(The People's Hospital of Yangdong District,Yangjiang 529931,China)
出处
《临床医学工程》
2019年第1期83-84,共2页
Clinical Medicine & Engineering
关键词
乙肝
肝硬化
代偿期
恩替卡韦
鳖甲煎丸
Hepatitis B
Liver cirrhosis
Compensatory period
Entecavir
Biejiajian pill
作者简介
许世申(1975-),男,广东阳江人,本科学历,副主任医师,从事内科临床工作。
