摘要
目的观察消癥抗癌方对早中期宫颈癌患者免疫功能、生活质量的影响及其安全性。方法将80例宫颈癌患者随机分为治疗组及对照组,每组各40例,两组予放疗后序贯完成紫杉醇加顺铂化疗,治疗组在此基础上加用消癥抗癌方,21天为1个周期,共4个周期。检测治疗前后免疫功能(CD3^+、CD4^+、CD8^+、NK百分比)、血常规、肝肾功能,记录治疗前后生活质量评分,观察治疗后化疗相关性恶心呕吐情况。结果治疗组CD3^+、CD4^+、NK细胞百分比及CD4^+/CD8^+分别为(68±7)%、(37±4)%、(26±3)%、(1.28±0.11),高于对照组[(61±6)%,(31±5)%,(22±3)%,(1.11±0.14),P<0.05],躯体功能、角色功能、总体健康状况优于对照组(P<0.01,P<0.05),治疗组骨髓抑制、腹泻发生率低于对照组(P<0.05)。两组化疗相关性恶心呕吐缓解情况差异无统计学意义(P>0.05)。结论消癥抗癌方可提高早中期宫颈癌患者免疫功能,改善生活质量,减轻放化疗不良反应。
Objective To investigate the effect of Xiaozheng Kang′ai Formula(XZKAF) on immune function and quality of life in early-and-intermediate stage cervical cancer patients and its safety. MethodsTotally 80 cervical cancer subjects were randomized into a treatment group and a control group,with 40 cases in each group.The control group were administered with sequential TP chemotherapy following radiation therapy while the treatment group were additionally administered with XZKAF. Twenty-one days were taken as one therapeutic course, 4 courses in total. Before and after treatment, the immune function(percentage of CD3^+,CD4^+,CD8^+ and NK), hematology, liver and kidney function were measured and the quality of life were assessed. Chemotherapy-related nausea and vomiting were observed.Results The percentages of CD3^+,CD4^+,NK cells and CD4^+/CD8^+[(68±7)%,(37±4)%,(26±3)%,(1.28±0.11)respectively] in the treatment group were higher than those[(61±6)%,(31±5)%,(22±3)%,(1.11±0.14) respectively] in the control group(P<0.05).The physical function, role function and overall health condition of the treatment group were better than those in the control group(P<0.01, P<0.05). The incidence of diarrhea and myelosuppression in the treatment group was lower than the control group(P<0.05). There was no significant difference in the chemotherapy-related nausea and vomiting between the two groups(P>0.05). Conclusion XZKAF can improve the immune function and quality of life in early-and-intermediate stage cervical cancer patients as well as to alleviate adverse effects of radiotherapy and chemotherapy.
作者
黄山
齐元杰
许金榜
张俊新
陈寿珍
黄丽萍
刘英
HUANG Shan;QI Yuan-jie;XU Jin-bang;ZHANG Jun-xin;CHENShou-zhen;HUANG Li-ping;LIU Ying(Department of Traditional Chinese Medicine,FujianProvincial Maternity and Children's Hospital,Fuzhou (350001);Department of Gynaecology,Fujian Pro- vincial Maternity and Children's Hospital,Fuzhou (350001))
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2019年第1期43-47,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
福建省卫生厅青年科研课题资助项目(No.2013-2-14)
关键词
消癥抗癌方
宫颈癌
早中期
细胞免疫功能
生活质量
Xiaozheng Kang'ai Formula
cervical cancer
early and intermediate stage
cellular immune function
quality of life
作者简介
通讯作者:刘英,Tel:13960874386,E—mail:fjLiuYing@163.com.
