摘要
间充质干细胞(MSC)外泌体是MSC在静息或活化状态下释放到细胞外基质中的膜性小囊泡,直径为30~150nm。最近的研究表明,MSC外泌体可作为重要的信号传导介质,有效转运mRNA、微小RNA和蛋白质等生物活性物质至靶细胞,在调控组织再生修复及免疫调节方面发挥重要作用。本文对MSC外泌体的生物学特性、作用机制及在脓毒症治疗中作用的研究进展作一综述,以期为临床治疗脓毒症提供依据。
Exosomes derived from mesenchymal stem cells (MSCs) are small membrane vesicles with diameters in 30-150 nm, which are secreted into extracellular matrix by MSCs in resting or activated state. Recent studies have found that exosomes secreted by MSCs can be used as important signal transduction mediator, which can transport bioactive substances such as mRNA, microRNA, and proteins effectively to target cells, and play important roles in regulating tissue regeneration and immunomodulation. Here we give an overview of biological properties, mechanisms, and the roles in treating sepsis of exosome derived from MSCs, in order to provide some basises to highlight the MSCs-exosomes therapy in sepsis.
作者
王珊
尹海燕
Wang Shan;Yin Haiyan(Department of Intensive Care Unit, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China)
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2019年第1期77-80,共4页
Chinese Journal of Burns
基金
广东省自然科学基金(2015A030313735)
广东省科技计划(2014A020212651).
作者简介
通信作者:尹海燕,Email:yinhaiyan1867@126.com.
