摘要
[目的]观察粪菌移植对腹泻型肠易激综合征的临床疗效。[方法]将42例腹泻型肠易激综合征患者随机分为治疗组和对照组,2组患者均进行生活饮食调理,给予口服益生菌制剂,治疗组在此基础上给予粪菌移植。对2组临床疗效进行评价,并记录不良反应。[结果]治疗组显效率(60.0%)高于对照组(18.5%),2组比较差异有统计学意义(χ~2=7.47,P<0.01);治疗组总有效率80.0%,对照组总有效率55.6%,2组比较差异无统计学意义(χ~2=2.51,P>0.05);2组治疗后菌群数量均较治疗前有增加,治疗组增加更显著;2组均未见明显不良反应。[结论]粪菌移植能有效缓解腹泻型肠易激综合征患者的临床症状,且不良反应少。
[Objective]To investigate the therapeutic effect of fecal microbiota transplantation on diarrhea predominant irritable bowel syndrome.[Methods]Forty-two cases of patients with IBS-D were divided randomly into observation group and control group.Both groups were given routine medical treatment such as diet adjustment and probiotics,the therapy group were treated with t fecal microbiota transplantation.Curative effect and adverse reaction were observed.[Results]The significant efficiency of the therapy group was higher than that of the control group(60.0% vs 18.5%,X^2=7.47,P<0.01).The total efficiency rate of the two groups had no significant difference(80.0% vs 55.6%,X^2=2.51,P>0.05).[Conclusions]The symptoms in patients with IBS-D can be relieved effectively by fecal microbiota transplantation with less adverse reaction.
作者
郭锐芳
董琳
康东
冶正财
邓燕红
马岚
刘晗
高丽萍
GUO Rui-fang;DONG Lin;KANG Dong;YE Zheng-cai;DENG Yan-hong;MA Lan;LIU Han;GAO Li-ping(The Peoples Hospital of Ningxia,Yinchuan 750004,China)
出处
《临床消化病杂志》
2018年第6期366-368,共3页
Chinese Journal of Clinical Gastroenterology
基金
宁夏卫生计生委重点研究课题(No:2015-NW-009)
关键词
腹泻型肠易激综合征
粪菌移植
临床疗效
diarrhea predominant irritable bowel syndrome
fecal microbiota transplantation
clinical effect
作者简介
通信作者,董琳,E-mail:grf4641075@163.com
