摘要
目的以正交试验结合指纹图谱和信息熵综合评价,优选复方白芷止痛胶囊的提取工艺。方法通过正交试验,选择绿原酸、阿魏酸、欧前胡素、异欧前胡素的提取率,浸膏得率结合指纹图谱相似度作为综合评价指标,采用信息熵赋权法确定各指标的客观权重,实现对提取工艺的正交试验优选。结果最佳提取工艺为以10倍量70%乙醇提取3次,每次1 h。结论以正交试验结合指纹图谱和信息熵综合评价优选提取工艺,专属性强、灵敏度高,可用于中药复方提取工艺优选。
Objective To optimize the extraction process parameters of Compound Baizhi Zhitong Capsule on the basis of orthogonal test combined with fingerprint and information entropy as comprehensive evaluation.Methods Orthogonal test was conducted to determine the extraction ratio,extract yield and fingerprint similarity of chlorogenic acid,ferulic acid,imperatorin,isoimperatorin as comprehensive evaluation indexes.Information entropy method was used to determine the objective weight of each index to achieve the orthogonal test optimization on extraction process.Results The optimum extraction process were as follows :extraction with 70% alcohol at 10 times amount of the drug weight for three times,each time for one hour.Conclusion The optimization of extraction process on the basis of orthogonal test combined fingerprint and information entropy can be used for optimizing the extraction process of Compound Chinese medicine,with high specificity and sensitirity.
作者
黄广伟
杨素德
曹婧迪
HUANG Guangwei;YANG Sude;CAO Jingdi(Shanghai Green Valley Pharmaceutical Co.,Ltd.,Shanghai 201707,China;Shanghai Compound Traditional Chinese Medicine (Green Valley)Engineering Technology Research Center,Shanghai 201707,China)
出处
《上海中医药杂志》
2018年第11期80-85,共6页
Shanghai Journal of Traditional Chinese Medicine
关键词
信息熵
正交试验
指纹图谱
阿魏酸
绿原酸
欧前胡素
异欧前胡素
information entropy
orthogonal test
fingerprint
ferulic acid
chlorogenic acid
imperatorin
isoimperatorin
作者简介
黄广伟,男,工程师,主要从事中药复方研究
