摘要
以水杨酸和乙酸酐作为原料,采用低共熔溶剂氯化胆碱-尿素作为反应介质和催化剂,考察不同反应条件对阿司匹林合成的影响。实验结果表明,在反应温度80℃、酸酐摩尔比1∶2.5、反应时间40min、氯化胆碱-尿素用量1.5g时,阿司匹林的收率达94%。
The influence of different reaction conditions on the synthesis of aspirin was investigated, by using salicylic acid and acetic anhydride as raw materials,and the deep eutectic solvent of choline chloride-urea as reaction medium and catalyst.The experimental results show that the yield of aspirin could reach 94%,using 80℃ of reaction temperature,1:2.5of molar ratio of salicylic acid to acetic anhydride,40min of reaction time,1.5 g of choline chloride-urea dosage.
作者
王英磊
陈鑫
常双强
李想
刘学国
张群安
Wang Yinglei;Chen Xin;Chang Shuangqiang;Li Xiang;Liu Xueguo;Zhang Qun'an(School of Biological and Chemical Engineering,Nanyang Institute of Technology,Nanyang 473004,He'nan,China;He'nan Key Laboratory of Industrial Microbial Resources and Fermentation Technology,Nanyang 473004,He'nan,China)
出处
《精细石油化工》
CAS
CSCD
北大核心
2018年第6期72-75,共4页
Speciality Petrochemicals
基金
河南省科技攻关项目(182102310601)
河南省高等学校重点科研项目(17B150007)
作者简介
王英磊(1986-),讲师,博士,主要从事精细化学品的绿色合成研究。E-mail:wangyinglei2014@163.com。
