摘要
[目的]观察健脾益心方联合西药治疗冠心病稳定型心绞痛(心脾两虚)疗效。[方法]使用随机平行对照方法,将80例门诊患者按就诊顺序号方法随机分为两组。对照组40例维拉帕米,100mg/次,3次/d;美托洛尔,100mg/次,2次/d;阿司匹林,100ng/次,3次/d;辛伐他汀,40mg/次,每晚口服;心绞痛发作时,硝酸甘油,0.5mg/次,舌下含服。治疗组40例健脾益心方(黄芪、党参、酸枣仁各30g,白术、茯苓、远志、佛手、延胡索、当归、红花、丹参各15g,甘草6g),水煎300mL,1剂/d,2次/d;西药治疗同对照组。连续治疗12周为1疗程。观测临床表现、心绞痛疗效、心电图疗效、硝酸甘油疗效、胆固醇(TC)、甘油三酯(TG)、高密度胆固醇(HDL-C)、低密度胆固醇(LDL-C)、不良反应。治疗1疗程(12周),判定疗效。[结果]心绞痛疗效:治疗组显效20例,有效11例,无效9例,总有效率77.50%;对照组显效10例,有效12例,无效18例,总有效率55.00%;治疗组疗效优于对照组(P<0.05)。心电图疗效:治疗组显效15例,有效10例,无效15例,总有效率65.50%;对照组显效7例,有效9例,无效24例,总有效率40.00%;治疗组疗效优于对照组(P<0.05)。硝酸甘油疗效:治疗组显效22例,有效10例,无效8例,总有效率80.00%;对照组显效14例,有效8例,无效18例,总有效率55.00%;治疗组疗效优于对照组(P<0.05)。TC、TG、HDL-C、LDL-C两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]健脾益心方联合西药治疗冠心病稳定型心绞痛(心脾两虚),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Jianpi Yixin Fang combined with western medicine on stable angina pectoris of coronary heart disease(Xinpi Liangxu).[Methods] Eighty outpatients were randomly divided into two groups according to the order of visiting.Control group 40 cases verapamil,100 mg/time,3 times/day;metoprolol,100 mg/time,2 times/day;aspirin,100 ng/time,3 times/day;simvastatin,40 mg/time,oral every night;angina attack,nitroglycerin,0.5 mg/time,sublingual.In the treatment group,40 cases were treated with Jianpi Yixin Fang(Huangqi,Dangshen,Suanzaoren each 30 g,Baizhu,Fuling.Yuanzhi,Foshou,Yanhusuo,Danggui,Honghua,Danshen each 15 g,Gancao 6 g),decoction 300 mL,western medicine treatment with the control group.Continuous treatment for 12 weeks was 1 courses.Clinical manifestations,angina pectoris,electrocardiogram,nitroglycerin,cholesterol(TC),triglyceride(TG),high density cholesterol(HDL-C),low density cholesterol(LDL-C),adverse reactions were observed.The course of treatment was 1 weeks(12 weeks),and the curative effect was judged.[Results] The curative effect of angina pectoris:the treatment group was markedly effective in 20 cases,effective in 11 cases,ineffective in 9 cases,the total effective rate was 77.50%;the control group was markedly effective in 10 cases,effective in 12 cases,ineffective in 18 cases,the total effective rate was 55.00%;the treatment group was better than thecontrol group(P<0.05).Electrocardiogram curative effect:the treatment group was markedly effective in 15 cases,effective in 10 cases,ineffective in 15 cases,the total effective rate was 65.50%;the control group was markedly effective in 7 cases,effective in 9 cases,ineffective in 24 cases,the total effective rate was 40.00%;the treatment group was better than the control group(P<0.05).Nitroglycerin treatment group:22 cases were markedly effective,10 cases were effective,8 cases were ineffective,the total effective rate was 80.00%;the control group was markedly effective in 14 cases,8 cases were effective,18 cases were ineffective,the total effective rate was 55.00%;the treatment group was better than the control group(P<0.05).TC,TG,HDL-C,LDL-C were improved in both groups(P<0.05,P<0.01),and the improvement in the treatment group was better than that in the control group(P<0.05,P<0.01).[Conclusion] Jianpi Yixin Fang combined with western medicine in treating stable angina pectoris of coronary heart disease(Xinpi Liangxu) has satisfactory curative effect and no serious adverse reactions,which is worth popularizing.
作者
蓝登科
LAN Dengke(Heshan Hospital of Traditional Chinese Medicine,Heshan 529700,Guangdong,China)
出处
《实用中医内科杂志》
2018年第10期21-24,共4页
Journal of Practical Traditional Chinese Internal Medicine
关键词
冠心病稳定心绞痛
胸痹
真心痛
心脾两虚
健脾益心方
维拉帕米
美托洛尔
阿司匹林
辛伐他汀
硝
酸甘油
心绞痛疗效
心电图疗效
硝酸甘油疗效
胆固醇
甘油三酯
高密度胆固醇
低密度胆固醇
中药复方
随机平行对照研究’.'
coronary heart disease stable angina pectoris
chest pain
true heart pain
Xinpi Liangxu(心脾两虚)
Jianpi Yixin decoction(健脾益心方)
verapamil
metoprolol
aspirin
simvastatin
nitroglycerin
angina pectoris effect,electrocardiogram effect
nitroglycerin effect
cholesterol
triglyceride
high density cholesterol
low density cholesterol
Chinese medicine compound
randomized parallel control study
