摘要
目的探讨各类型肝病的出凝血指标与血小板参数关系。方法收集2016年1月至2017年12月于本院住院治疗的肝病患者共83例,分为慢性乙型肝炎组(32例)、肝硬化组(51例)及对照组(85例),回顾分析患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)以及血小板计数(PLT)、血小板分布宽度(PDW)、血小板平均体积(MPV)和血小板平压积(PCT)。结果 (1)慢性乙型肝炎组、肝硬化组PT、APTT均延长,FIB减少,与对照组相比,差异有统计学意义(P <0. 05);肝硬化组与慢性乙型肝炎组相比,APTT、PT与FIB均有统计学意义(P<0.05)。(2)肝硬化组和慢性乙型肝炎组PLT和PCT均减少,MPV、PDW均升高,与对照组相比,差异具有统计学意义(P <0.05);肝硬化的PLT和PCT低于慢性乙型肝炎组,MPV高于慢性乙型肝炎组(P<0.05)。结论血小板参数和凝血指标在不同类型的肝病变化不同,通过监测血小板参数和凝血指标可以为临床肝病的诊断、预后及用药提供一定的参考意义。
Objective To investigate the relationships between blood coagulation indexes and platelet parameters of various types of liver diseases. Methods 83 inpatients having liver disease collected from January 2016 to December 2017 in our hospital were divided into the chronic hepatitis B group(32 cases) and the liver cirrhosis group(51 cases), while the control group(85 cases of non-liver disease patients) were collected at the same period. The results of prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB),along with platelet count(PLT),platelet distribution width(PDW),mean platelet volume(MPV) and platelet hematocrit level(PCT) were retrospectively analyzed. Results(1) Compared with the control group,PT and APTT in patients with chronic hepatitis B and cirrhosis were increased,and FIB were decreased with significant differences(P <0.05); Compared with the chronic hepatitis B group, APTT,PT and FIB in the liver cirrhosis groups were significantly different(P<0. 05).(2) Compared with the control group,the PLT and PCT levels in the liver cirrhosis and chronic hepatitis B group decreased(P <0.05), and MPV, and PDW increased significantly. The PLT and PCT levels in liver cirrhosis were lower than those of chronic hepatitis B,while MPV was higher than those of chronic hepatitis B. Conclusion Platelet parameters and coagulation indicators will be varied in different types of liver diseases and can be useful in clinical diagnosis, prognosis and treatment of liver diseases.
作者
孙艳虹
钟威
朱秋婕
SUN Yan-hong;ZHONG Wei;ZHU Qiu-jie(Department of Clinical Laboratoy,The Eastern Hospital of the First Affifiated Hospital,SunYat-sen University,Guangzhou 510700,China)
出处
《标记免疫分析与临床》
CAS
2018年第11期1603-1606,共4页
Labeled Immunoassays and Clinical Medicine
关键词
肝硬化
慢性乙型肝炎
凝血指标
血小板参数
Liver cirrhosis
Chronic hepatitis B
Coagulation index
Platelet parameters
