摘要
目的评估玉溪市红塔区开展艾滋病"一站式服务"的效果。方法数据来源于艾滋病综合防治数据信息系统中的病例报告卡数据库和随访数据库等,将2013-2014年未开展"一站式服务"者设为对照组,2015年1月-2016年6月开展"一站式服务"者设为观察组,比较该两组研究对象抗病毒治疗及时情况、治疗效果及随访情况,分析新报告病例半年内死亡率。结果对照组(139例)与观察组(126例)人口学特征差异不显著,初筛后对照组和观察组及时治疗率分别为29. 50%和70. 63%,差异有统计学意义(P <0. 05)。对照组中50岁以上人群,初中及以上学历者、未婚/离异/丧偶者、非农民、样本来源于医疗机构及其他者、CD4^+T细胞计数越高者ART不及时率较高;观察组中未婚/离异/丧偶者、CD4^+T细胞计数越高者ART不及时率较高。对照组17. 65%、观察组15. 04%免疫应答失败,对照组16. 47%、观察组13. 27%病毒学治疗失败,但是服药规范性及完成4次随访情况有较大改善(P均<0. 05),新报告半年内死亡率尚未观察到改善情况。结论 "一站式服务"能够有效提高新报告HIV/AIDS的ART获得及时率及服药规范率和随访率。
Objective To evaluate the utility of HIV/AIDS "one-stop service"in Hongta district,Yuxi prefecture. Methods Data were collected from HIV/AIDS case report cards,follow-up cards and the original records. Patients,who joined before the initiation of one-stop service,between 2013 and 2014,were defined as control group,while patients who received the one-stop service between January 2015 and June 2016 were defined as observation group. We comparatively analyzed the difference in the antiretroviral therapy( ART) initiation and its duration,compliance to ART,semi-annual mortality rate and the rate of completion of four follow ups between two groups. Results There were 139 and 126 newly detected HIV/AIDS cases divided into control group and observation group,respectively. There was no significant difference in the demographic characteristics between both groups. Of those patients,who had success-fully initiated ART within one months after HIV screening,29. 5% were in the control group and 71. 0% in the observation group( P < 0. 05). Logistic regression analysis indicated that in control group there was a higher ratio of patients older than 50 years old,whose education level were junior high school or above,who were single,divorced or widowed,farmers,diagnosed through hospital setting and other,and those with higher CD4^+T cell counts were likely to receive late treatment. In observation group there were more single,divorced or widowed individuals than married individuals,and those with higher CD4^+T cell counts were likely to receive late treatment. The 17. 6% and15. 0% of patients failed to show immunological responses and 16. 5% and 13. 3%failed to achieve virological responses in control and observation group,respectively.The compliance to ART and finishing follow ups were improved in observation group( P < 0. 05),but the semi-annual mortality rate did not improve in observation group.Conclusion The ART initiation and its duration,compliance to ART and the completion of follow ups were improved through initiation of HIV/AIDS "one-stop service".
作者
蔡英
李世福
董文斌
赵金仙
朱永芬
陈黎跃
鲁建波
CAI Ying;LI Shifu;DONG Wenbin;ZHAO Jinxian;ZHU Yongfen;CHEN Liyue;LU Jianbo(Yuxi Centre for Disease Control and Prevention,Yuxi 653100,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2018年第12期1432-1437,共6页
The Chinese Journal of Dermatovenereology
关键词
艾滋病
ART
一站式服务
及时率
Acquired immunodeficiency syndrome
Antiviral therapy
One-stop service
Timeliness rate
作者简介
通讯作者:李世福,E—mail:shifu208@163.com。
