摘要
目的 探讨适合我国人工机械瓣膜置换术后病人特点的抗凝治疗强度标准。方法 对40 7例置换人工机械瓣膜的病人 ,采用了低强度的抗凝标准 (INR 1 3～ 2 3) ,通过对这组病人的术后随访 ,总结不同抗凝标准时人工机械瓣膜各种并发症的发生率。结果 本组发生血栓栓塞 8例 (1 0 9%人年 ) ,发生与抗凝有关的出血 5例 (0 6 8%人年 ) ,3年生存率为 (96 3± 1 2 ) %。最终INR 1 85± 0 2 8,口服华法林剂量 (2 7± 0 9)mg。结论 采用低强度抗凝治疗标准 ,在我国病人中 ,不仅能够获得满意的预防血栓栓塞发生的效果 。
Objective: The purpose of this study was to define the Chinese optimal intensity of oral anticoagulant therapy following mechanical valve replacement. Methods: 407 patients received low intensity of oral anticoagulant therapy following mechanical heart valve prostheses replacement. They were evaluated for valve related complications. Results: During the period of follow up, 8 thromboembolic and 5 hemorrhage complications occured. The total linearized rate of thromboembolism was 1 09%pty. The total freedom from thromboembolism was (97 5±0 9)% at two years. The total linearized rate of anticoagulation related bleeding was 0 68%pty. The total freedom from anticoagulation related bleeding was (98 3±0 8)% at two years. The total survival was (96 3±1 2)% at three years. The final mean INR was 1 85±0 28. The final mean oral anticoagulant dose was (2 7±0 9) mg. Conclusion: In Chinese patients with mechanical heart valve prostheses, a low intensity level (INR 1 3-2 3) may prevent thrombolic events as effectively as conventional anticoagulation and reduce the incidence of hemorrhagic events.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2001年第5期263-265,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
人工机械瓣膜
随访研究
抗凝治疗
Heart valve prosthese Follow up studies Anticoagulants
